Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17592991 | 0.89 | LMNA (0.38) | ALDH1A1GAAPOLBKMT2AMEN1 | |
| SCHEMBL17593148 | 0.70 | ADRB2 (0.44) | POLBKMT2AMEN1TSHRMAPT | |
| SCHEMBL17593165 | 0.67 | TRIM24 (0.49) | POLBKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL1528397 | 0.64 | NPC1 (0.69) | ALDH1A1POLBLMNATSHRMAPT | |
| SCHEMBL17593239 | 0.62 | PHGDH (0.54) | GAATP53KMT2AMEN1LMNA | |
| SCHEMBL29930951 | 0.60 | HSD17B10 (0.60) | ALDH1A1POLBKMT2AMEN1MAPT | |
| SCHEMBL71938 | 0.60 | HSD17B10 (0.60) | ALDH1A1POLBKMT2AMEN1MAPT | |
| SCHEMBL17593076 | 0.59 | NPC1 (0.44) | GAATP53POLBKMT2AMEN1 | |
| SCHEMBL23611759 | 0.59 | HSD17B10 (0.62) | ALDH1A1GAAPOLBKMT2AMEN1 | |
| SCHEMBL29930704 | 0.59 | HSD17B10 (0.62) | ALDH1A1GAAPOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040449-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |