Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599392 | 0.85 | CCKBR (0.47) | CCKBRTDP1NPC1RAB9AACLY | |
| SCHEMBL17599398 | 0.84 | BRD4 (0.41) | TDP1KMT2ABRD4MCL1ACLY | |
| SCHEMBL17599350 | 0.84 | LMNA (0.55) | TDP1KMT2ABRD4MCL1ACLY | |
| SCHEMBL17599325 | 0.84 | TDP1 (0.39) | CCKBRTDP1KMT2ABRD4MCL1 | |
| SCHEMBL17599365 | 0.84 | TDP1 (0.41) | TDP1KMT2ABRD4MCL1ACLY | |
| SCHEMBL17613352 | 0.83 | BRD4 (0.40) | TDP1KMT2ABRD4MCL1ACLY | |
| SCHEMBL17599403 | 0.77 | WDR5 (0.49) | TDP1KMT2ABRD4MCL1ACLY | |
| SCHEMBL17599351 | 0.77 | KMT2A (0.45) | TDP1KMT2ABRD4MCL1NPC1 | |
| SCHEMBL17599382 | 0.77 | WDR5 (0.45) | TDP1KMT2AMCL1ACLYFABP4 | |
| SCHEMBL17599388 | 0.77 | ACLY (0.48) | TDP1KMT2ABRD4MCL1ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |