Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599398 | 0.95 | BRD4 (0.41) | BRD4MCL1TDP1KMT2ASLC16A3 | |
| SCHEMBL17599365 | 0.87 | TDP1 (0.41) | BRD4MCL1TDP1KMT2ASLC16A3 | |
| SCHEMBL17599322 | 0.83 | CCKBR (0.48) | BRD4MCL1TDP1KMT2AACLY | |
| SCHEMBL17599413 | 0.83 | BRD4 (0.40) | BRD4MCL1TDP1KMT2APTPN11 | |
| SCHEMBL17599355 | 0.81 | PTK2B (0.43) | BRD4TDP1SLC16A3ACLYRAD52 | |
| SCHEMBL17599325 | 0.80 | TDP1 (0.39) | BRD4MCL1TDP1KMT2AACLY | |
| SCHEMBL17599388 | 0.75 | ACLY (0.48) | BRD4MCL1TDP1KMT2AACLY | |
| SCHEMBL17599403 | 0.74 | WDR5 (0.49) | BRD4MCL1TDP1KMT2ASLC16A3 | |
| SCHEMBL17599351 | 0.74 | KMT2A (0.45) | BRD4MCL1TDP1KMT2ASLC16A3 | |
| SCHEMBL17599382 | 0.73 | WDR5 (0.45) | MCL1TDP1KMT2ASLC16A3ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |