Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 6/20 | 0.41 |
| ▸ | ACLY | P53396 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | USP8 | P40818 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599326 | 0.85 | KEAP1 (0.46) | KEAP1NR1H4PPARAACLYGAA | |
| SCHEMBL17599390 | 0.76 | KEAP1 (0.56) | KEAP1NR1H4PPARAACLYALDH1A1 | |
| SCHEMBL17599372 | 0.72 | ALDH1A1 (0.62) | KEAP1ACLYGAAALDH1A1MEN1 | |
| SCHEMBL17599341 | 0.68 | FABP4 (0.43) | KEAP1ACLYALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL17599309 | 0.68 | NPC1 (0.52) | NR1H4PPARAGAAPPARGALDH1A1 | |
| SCHEMBL17599343 | 0.68 | KEAP1 (0.46) | KEAP1ACLYKMT2A | |
| SCHEMBL1093957 | 0.65 | KDM1A (0.62) | ACLYGAAALDH1A1KDM1AMEN1 | |
| SCHEMBL17599444 | 0.64 | KEAP1 (1.00) | KEAP1PPARAGAAPPARGPPARD | |
| SCHEMBL17599331 | 0.64 | PIK3CG (0.45) | KEAP1KMT2A | |
| SCHEMBL981341 | 0.64 | SMN1; SMN2 (0.71) | NR1H4PPARAGAAPPARGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |