Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 3/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | PFKFB4 | Q16877 | 3/20 | 0.38 |
| ▸ | ACLY | P53396 | 2/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.37 |
| ▸ | PTGFR | P43088 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599326 | 0.84 | KEAP1 (0.46) | FABP4KEAP1SMN1; SMN2ACLYPTGFR | |
| SCHEMBL17599343 | 0.84 | KEAP1 (0.46) | KEAP1KMT2APFKFB4ACLYPFKFB3 | |
| SCHEMBL17599385 | 0.81 | TSHR (0.47) | FABP4PTK2BSMN1; SMN2KMT2ASLC16A3 | |
| SCHEMBL17613337 | 0.80 | PFKFB3 (0.63) | KEAP1PFKFB4CMA1PFKFB3 | |
| SCHEMBL17599370 | 0.79 | ALDH1A1 (0.53) | FABP4KEAP1PTK2BSMN1; SMN2KMT2A | |
| SCHEMBL17599305 | 0.79 | ACLY (0.55) | FABP4PTK2BSMN1; SMN2SLC16A3ACLY | |
| SCHEMBL17599320 | 0.78 | SMN1; SMN2 (0.54) | FABP4PTK2BSMN1; SMN2KMT2ASLC16A3 | |
| SCHEMBL17599411 | 0.77 | TDP1 (0.55) | FABP4PTK2BSMN1; SMN2SLC16A3ACLY | |
| SCHEMBL17599333 | 0.77 | PTK2B (0.52) | FABP4PTK2BSMN1; SMN2KMT2ASLC16A3 | |
| SCHEMBL17599390 | 0.76 | KEAP1 (0.56) | KEAP1SMN1; SMN2KMT2ASLC16A3PFKFB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |