Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 7/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 3/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599355 | 0.89 | PTK2B (0.43) | FABP4PTK2BSMN1; SMN2ACLYRAD52 | |
| SCHEMBL17599365 | 0.86 | TDP1 (0.41) | FABP4ACLYRAD52TDP1ERAP2 | |
| SCHEMBL17599392 | 0.84 | CCKBR (0.47) | FABP4PTK2BSMN1; SMN2ACLYRAD52 | |
| SCHEMBL17599311 | 0.81 | PTK2B (0.43) | FABP4PTK2BSMN1; SMN2ACLYRAD52 | |
| SCHEMBL17599399 | 0.76 | PTK2B (0.57) | FABP4PTK2BSMN1; SMN2ACLYFABP5 | |
| SCHEMBL17599385 | 0.76 | TSHR (0.47) | FABP4PTK2BSMN1; SMN2ACLYRAD52 | |
| SCHEMBL17599333 | 0.76 | PTK2B (0.52) | FABP4PTK2BSMN1; SMN2ACLYRAD52 | |
| SCHEMBL17599412 | 0.76 | FABP4 (0.45) | FABP4PTK2BSMN1; SMN2ACLYFABP5 | |
| SCHEMBL17599320 | 0.75 | SMN1; SMN2 (0.54) | FABP4PTK2BSMN1; SMN2ACLYTDP1 | |
| SCHEMBL17599391 | 0.75 | FABP4 (0.61) | FABP4ACLYRAD52TDP1ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |