Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599385 | 0.90 | TSHR (0.47) | SMN1; SMN2LMNAMAPK1PTK2BFABP4 | |
| SCHEMBL17599350 | 0.86 | LMNA (0.55) | SMN1; SMN2LMNAMAPK1POLBKDM4E | |
| SCHEMBL17599392 | 0.85 | CCKBR (0.47) | SMN1; SMN2TDP1PTK2BFABP4ACLY | |
| SCHEMBL17599305 | 0.85 | ACLY (0.55) | SMN1; SMN2LMNAMAPK1PTK2BFABP4 | |
| SCHEMBL17613353 | 0.83 | FABP4 (0.38) | SMN1; SMN2LMNAMAPK1PTK2BFABP4 | |
| SCHEMBL17599370 | 0.82 | ALDH1A1 (0.53) | SMN1; SMN2KDM4EPTK2BFABP4HTT | |
| SCHEMBL17599341 | 0.78 | FABP4 (0.43) | SMN1; SMN2PTK2BFABP4ACLYSLC16A3 | |
| SCHEMBL17599338 | 0.76 | FABP4 (0.42) | SMN1; SMN2PTK2BFABP4ACLYSLC16A3 | |
| SCHEMBL17599412 | 0.76 | FABP4 (0.45) | SMN1; SMN2PTK2BFABP4ACLYSLC16A3 | |
| SCHEMBL17599387 | 0.76 | FABP4 (0.56) | SMN1; SMN2LMNAPOLBKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |