Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ACLY | P53396 | 4/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | FABP4 | P15090 | 3/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599305 | 0.92 | ACLY (0.55) | TSHRACLYPTK2BSMN1; SMN2FABP4 | |
| SCHEMBL17599320 | 0.90 | SMN1; SMN2 (0.54) | ACLYPTK2BSMN1; SMN2FABP4LMNA | |
| SCHEMBL17599388 | 0.85 | ACLY (0.48) | TSHRACLYSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL17613353 | 0.85 | FABP4 (0.38) | ACLYPTK2BSMN1; SMN2FABP4LMNA | |
| SCHEMBL17599370 | 0.83 | ALDH1A1 (0.53) | ACLYPTK2BSMN1; SMN2FABP4SLC16A3 | |
| SCHEMBL17599341 | 0.81 | FABP4 (0.43) | ACLYPTK2BSMN1; SMN2FABP4SLC16A3 | |
| SCHEMBL17599338 | 0.79 | FABP4 (0.42) | ACLYPTK2BSMN1; SMN2FABP4SLC16A3 | |
| SCHEMBL17599412 | 0.79 | FABP4 (0.45) | ACLYPTK2BSMN1; SMN2FABP4SLC16A3 | |
| SCHEMBL17599392 | 0.79 | CCKBR (0.47) | ACLYPTK2BSMN1; SMN2FABP4SLC16A3 | |
| SCHEMBL17599355 | 0.78 | PTK2B (0.43) | ACLYPTK2BSMN1; SMN2FABP4SLC16A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | claimed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |