Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 5/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | BLVRB | P30043 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599329 | 0.84 | KMT2A (0.55) | KMT2ABRD4FABP4ACLYAKR1C3 | |
| SCHEMBL17599342 | 0.84 | FABP4 (0.45) | KMT2AFABP4FABP5ACLYSLC16A3 | |
| SCHEMBL17599310 | 0.83 | PTK2B (0.53) | KMT2AFABP4FABP5ACLYPTK2B | |
| SCHEMBL17599337 | 0.83 | PTK2B (0.50) | KMT2AFABP4FABP5ACLYSLC16A3 | |
| SCHEMBL17599303 | 0.82 | MCL1 (0.45) | KMT2AACLYMCL1PTK2BKDM4E | |
| SCHEMBL17599368 | 0.81 | KDM4E (0.48) | KMT2AKAT6AFABP4ACLYAKR1C3 | |
| SCHEMBL17599402 | 0.81 | BRD4 (0.52) | KMT2ABRD4FABP4FABP5ACLY | |
| SCHEMBL17599312 | 0.81 | KEAP1 (0.61) | KMT2AMCL1KDM4E | |
| SCHEMBL17599353 | 0.81 | ACLY (0.58) | KMT2AACLYMCL1PTK2BKDM4E | |
| SCHEMBL17599317 | 0.80 | FABP4 (0.52) | KMT2AKAT6AFABP4FABP5ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |