Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2B | Q14289 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | G6PD | P11413 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 3/20 | 0.47 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.47 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 7/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599317 | 0.87 | FABP4 (0.52) | PTK2BSMN1; SMN2KMT2AMEN1GAA | |
| SCHEMBL17599362 | 0.85 | KMT2A (0.46) | SMN1; SMN2KMT2AMEN1GAAG6PD | |
| SCHEMBL17599376 | 0.84 | FABP4 (0.56) | KMT2AMEN1GAAG6PDFABP4 | |
| SCHEMBL17599312 | 0.84 | KEAP1 (0.61) | KMT2AMEN1GAA | |
| SCHEMBL17599310 | 0.84 | PTK2B (0.53) | PTK2BSMN1; SMN2KMT2AFABP4FABP5 | |
| SCHEMBL17599400 | 0.83 | KMT2A (0.49) | PTK2BSMN1; SMN2KMT2AFABP4FABP5 | |
| SCHEMBL17599342 | 0.82 | FABP4 (0.45) | PTK2BSMN1; SMN2KMT2AFABP4FABP5 | |
| SCHEMBL17599404 | 0.82 | KMT2A (0.48) | KMT2AMEN1GAAG6PDFABP4 | |
| SCHEMBL17599319 | 0.81 | ACLY (0.46) | PTK2BSMN1; SMN2KMT2AFABP4FABP5 | |
| SCHEMBL17599403 | 0.80 | WDR5 (0.49) | PTK2BSMN1; SMN2KMT2AMEN1FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |