Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20348924 | 0.93 | GABRA1 (0.34) | GABRA1GABRB2ALDH1A1TACR1KIF11 | |
| SCHEMBL17600537 | 0.84 | KIF11 (0.41) | GABRA1GABRB2ALDH1A1TACR1KIF11 | |
| SCHEMBL20348925 | 0.81 | ALDH1A1 (0.33) | GABRA1GABRB2ALDH1A1KIF11 | |
| SCHEMBL17625238 | 0.80 | KDM4E (0.33) | ALDH1A1KDM4EPOLB | |
| SCHEMBL17642491 | 0.80 | PTPN2 (0.41) | GABRA1GABRB2ALDH1A1TACR1KIF11 | |
| SCHEMBL17629725 | 0.79 | ALDH1A1 (0.35) | GABRA1GABRB2ALDH1A1KIF11GABRG2 | |
| SCHEMBL17625653 | 0.79 | ALDH1A1 (0.35) | ALDH1A1TACR1PTPN2PTPN1PTPN6 | |
| SCHEMBL17625265 | 0.79 | GABRA1 (0.36) | GABRA1GABRB2ALDH1A1KIF11GABRG2 | |
| SCHEMBL17642496 | 0.78 | KIF11 (0.37) | GABRA1GABRB2ALDH1A1KIF11GABRG2 | |
| SCHEMBL17642475 | 0.77 | TDP1 (0.37) | GABRA1GABRB2KIF11GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938241-B2 | Diazirine compounds and compositions derived therefrom | PROMERUS, LLC (US) | 2018-04-10 | — | — | US | claimed |
| EP-3197881-A1 | DIAZIRINE COMPOUNDS AS PHOTOCROSSLINKERS AND PHOTOIMAGEABLE COMPOSITIONS COMPRISING THEM | Promerus, LLC (US) | 2017-08-02 | — | — | EP | claimed |
| WO-2016049123-A1 | DIAZIRINE COMPOUNDS AS PHOTOCROSSLINKERS AND PHOTOIMAGEABLE COMPOSITIONS COMPRISING THEM | PROMERUS, LLC (US) | 2016-03-31 | — | — | WO | claimed |
| US-20160083352-A1 | DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM | SUMITOMO BAKELITE CO., LTD. (JP) | 2016-03-24 | — | — | US | claimed |
| US-10303060-B2 | Diazirine compounds and compositions derived therefrom | PROMERUS, LLC (US) | 2019-05-28 | — | — | US | disclosed |
| US-20180186747-A1 | DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM | PROMERUS, LLC (US) | 2018-07-05 | — | — | US | disclosed |
| US-20180186747-A1 | DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM | PROMERUS, LLC (US) | 2018-07-05 | — | — | US | disclosed |
| WO-2016049123-A1 | DIAZIRINE COMPOUNDS AS PHOTOCROSSLINKERS AND PHOTOIMAGEABLE COMPOSITIONS COMPRISING THEM | PROMERUS, LLC (US) | 2016-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160083352-A1 | DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM | RDX, AOX1, ALDH1A2 | GABRA1 1904/4885GABRB2 2144/4885ALDH1A1 24/4885 |
| US-20180186747-A1 | DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM | ZYX, AOX1, RDX | GABRA1 1150/4885GABRB2 1211/4885ALDH1A1 145/4885 |
| US-10303060-B2 | Diazirine compounds and compositions derived therefrom | ZYX, AOX1, RDX | GABRA1 1150/4885GABRB2 1211/4885ALDH1A1 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.