SCHEMBL17600537

SCHEMBL17600537

FC(F)(F)C1(c2ccc(COCc3ccc(C4(C(F)(F)F)N=N4)cc3)cc2)N=N1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.41
GABRA1 P14867 3/20 0.37
GABRB2 P47870 2/20 0.37
TSHR P16473 1/20 0.37
GABRG2 P18507 1/20 0.36
GABRB3 P28472 1/20 0.36
ALDH1A1 P00352 2/20 0.35
NOS1 P29475 1/20 0.34
ABCB1 P08183 2/20 0.34
IDO1 P14902 2/20 0.33
PTPN2 P17706 1/20 0.33
PTPN1 P18031 1/20 0.33
PTPN6 P29350 1/20 0.33
TACR1 P25103 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
ADORA2A P29274 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17642491 0.91 PTPN2 (0.41) KIF11GABRA1GABRB2GABRG2GABRB3
SCHEMBL17625265 0.90 GABRA1 (0.36) KIF11GABRA1GABRB2TSHRGABRG2
SCHEMBL17642496 0.90 KIF11 (0.37) KIF11GABRA1GABRB2GABRG2GABRB3
SCHEMBL17600548 0.88 KIF11 (0.36) KIF11GABRA1GABRB2GABRG2GABRB3
SCHEMBL17642475 0.88 TDP1 (0.37) KIF11GABRA1GABRB2GABRG2GABRB3
SCHEMBL17600542 0.85 L3MBTL1 (0.38) KIF11GABRA1GABRB2GABRG2GABRB3
SCHEMBL24392635 0.85 GABRA1 (0.33) KIF11GABRA1GABRB2
SCHEMBL17629725 0.84 ALDH1A1 (0.35) KIF11GABRA1GABRB2GABRG2GABRB3
SCHEMBL12851359 0.84 KIF11 (0.43) KIF11GABRA1GABRB2ALDH1A1NOS1
SCHEMBL17600540 0.84 GABRA1 (0.37) KIF11GABRA1GABRB2GABRG2GABRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240336599-A1 PHOTOSENSITIVE POLYAMIC ACID AND DIAZIRINE COMPOSITIONS PROMERUS, LLC (US) 2024-10-10 US claimed
EP-4237461-A1 SHELF LIFE STABLE AND IMPROVED MASS POLYMERIZABLE POLYCYCLIC-OLEFINIC COMPOSITIONS Promerus, LLC (US) 2023-09-06 EP claimed
EP-4237460-A1 POLYCYCLIC-OLEFINIC COMPOSITIONS FOR LOW-LOSS FILMS HAVING IMPROVED THERMAL PROPERTIES Promerus, LLC (US) 2023-09-06 EP claimed
EP-3433884-B1 DIAZIRINE CONTAINING ORGANIC ELECTRONIC COMPOSITIONS AND DEVICE THEREOF PROMERUS LLC (US) 2023-01-11 EP claimed
US-20220135832-A1 SHELF LIFE STABLE AND IMPROVED MASS POLYMERIZABLE POLYCYCLIC-OLEFINIC COMPOSITIONS PROMERUS, LLC (US) 2022-05-05 US claimed
WO-2022094236-A1 SHELF LIFE STABLE AND IMPROVED MASS POLYMERIZABLE POLYCYCLIC-OLEFINIC COMPOSITIONS PROMERUS, LLC (US) 2022-05-05 WO claimed
WO-2022094232-A1 POLYCYCLIC-OLEFINIC COMPOSITIONS FOR LOW-LOSS FILMS HAVING IMPROVED THERMAL PROPERTIES PROMERUS, LLC (US) 2022-05-05 WO claimed
US-10693072-B2 Diazirine containing organic electronic compositions and device thereof PROMERUS, LLC (US) 2020-06-23 US claimed
EP-3197881-B1 DIAZIRINE COMPOUNDS AS PHOTOCROSSLINKERS AND PHOTOIMAGEABLE COMPOSITIONS COMPRISING THEM PROMERUS LLC (US) 2020-04-29 EP claimed
US-10303060-B2 Diazirine compounds and compositions derived therefrom PROMERUS, LLC (US) 2019-05-28 US claimed
US-20190157558-A1 DIAZIRINE CONTAINING ORGANIC ELECTRONIC COMPOSITIONS AND DEVICE THEREOF PROMERUS, LLC (US) 2019-05-23 US claimed
US-10256409-B2 Diazirine containing organic electronic compositions and device thereof PROMERUS, LLC (US) 2019-04-09 US claimed
EP-3433884-A1 DIAZIRINE CONTAINING ORGANIC ELECTRONIC COMPOSITIONS AND DEVICE THEREOF Promerus, LLC (US) 2019-01-30 EP claimed
US-20180186747-A1 DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM PROMERUS, LLC (US) 2018-07-05 US claimed
US-9938241-B2 Diazirine compounds and compositions derived therefrom PROMERUS, LLC (US) 2018-04-10 US claimed
US-20170279048-A1 DIAZIRINE CONTAINING ORGANIC ELECTRONIC COMPOSITIONS AND DEVICE THEREOF PROMERUS, LLC (US) 2017-09-28 US claimed
EP-3197881-A1 DIAZIRINE COMPOUNDS AS PHOTOCROSSLINKERS AND PHOTOIMAGEABLE COMPOSITIONS COMPRISING THEM Promerus, LLC (US) 2017-08-02 EP claimed
WO-2016049123-A1 DIAZIRINE COMPOUNDS AS PHOTOCROSSLINKERS AND PHOTOIMAGEABLE COMPOSITIONS COMPRISING THEM PROMERUS, LLC (US) 2016-03-31 WO claimed
US-20160083352-A1 DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM SUMITOMO BAKELITE CO., LTD. (JP) 2016-03-24 US claimed
US-12180385-B2 Shelf life stable and improved mass polymerizable polycyclic-olefinic compositions PROMERYS, LLC (US) 2024-12-31 US disclosed
US-20240376339-A1 PHOTOSENSITIVE POLYCYCLIC-OLEFINIC POLYMERS AND DIAZIRINE COMPOSITIONS FOR LOW-LOSS FILMS HAVING IMPROVED PROPERTIES PROMERUS, LLC (US) 2024-11-14 US disclosed
US-20240336599-A1 PHOTOSENSITIVE POLYAMIC ACID AND DIAZIRINE COMPOSITIONS PROMERUS, LLC (US) 2024-10-10 US disclosed
US-11845880-B2 Polycyclic-olefinic compositions for low-loss films having improved thermal properties PROMERUS, LLC (US) 2023-12-19 US disclosed
EP-4237461-A1 SHELF LIFE STABLE AND IMPROVED MASS POLYMERIZABLE POLYCYCLIC-OLEFINIC COMPOSITIONS Promerus, LLC (US) 2023-09-06 EP disclosed
EP-4237460-A1 POLYCYCLIC-OLEFINIC COMPOSITIONS FOR LOW-LOSS FILMS HAVING IMPROVED THERMAL PROPERTIES Promerus, LLC (US) 2023-09-06 EP disclosed
EP-3433884-B1 DIAZIRINE CONTAINING ORGANIC ELECTRONIC COMPOSITIONS AND DEVICE THEREOF PROMERUS LLC (US) 2023-01-11 EP disclosed
EP-3433884-B1 DIAZIRINE CONTAINING ORGANIC ELECTRONIC COMPOSITIONS AND DEVICE THEREOF PROMERUS LLC (US) 2023-01-11 EP disclosed
WO-2022094232-A1 POLYCYCLIC-OLEFINIC COMPOSITIONS FOR LOW-LOSS FILMS HAVING IMPROVED THERMAL PROPERTIES PROMERUS, LLC (US) 2022-05-05 WO disclosed
WO-2022094236-A1 SHELF LIFE STABLE AND IMPROVED MASS POLYMERIZABLE POLYCYCLIC-OLEFINIC COMPOSITIONS PROMERUS, LLC (US) 2022-05-05 WO disclosed
WO-2022094236-A1 SHELF LIFE STABLE AND IMPROVED MASS POLYMERIZABLE POLYCYCLIC-OLEFINIC COMPOSITIONS PROMERUS, LLC (US) 2022-05-05 WO disclosed
WO-2022094232-A1 POLYCYCLIC-OLEFINIC COMPOSITIONS FOR LOW-LOSS FILMS HAVING IMPROVED THERMAL PROPERTIES PROMERUS, LLC (US) 2022-05-05 WO disclosed
US-20220135832-A1 SHELF LIFE STABLE AND IMPROVED MASS POLYMERIZABLE POLYCYCLIC-OLEFINIC COMPOSITIONS PROMERUS, LLC (US) 2022-05-05 US disclosed
US-20220135831-A1 POLYCYCLIC-OLEFINIC COMPOSITIONS FOR LOW-LOSS FILMS HAVING IMPROVED THERMAL PROPERTIES PROMERUS, LLC (US) 2022-05-05 US disclosed
US-20220135832-A1 SHELF LIFE STABLE AND IMPROVED MASS POLYMERIZABLE POLYCYCLIC-OLEFINIC COMPOSITIONS PROMERUS, LLC (US) 2022-05-05 US disclosed
US-10693072-B2 Diazirine containing organic electronic compositions and device thereof PROMERUS, LLC (US) 2020-06-23 US disclosed
US-10693072-B2 Diazirine containing organic electronic compositions and device thereof PROMERUS, LLC (US) 2020-06-23 US disclosed
EP-3197881-B1 DIAZIRINE COMPOUNDS AS PHOTOCROSSLINKERS AND PHOTOIMAGEABLE COMPOSITIONS COMPRISING THEM PROMERUS LLC (US) 2020-04-29 EP disclosed
US-10303060-B2 Diazirine compounds and compositions derived therefrom PROMERUS, LLC (US) 2019-05-28 US disclosed
US-10303060-B2 Diazirine compounds and compositions derived therefrom PROMERUS, LLC (US) 2019-05-28 US disclosed
US-20190157558-A1 DIAZIRINE CONTAINING ORGANIC ELECTRONIC COMPOSITIONS AND DEVICE THEREOF PROMERUS, LLC (US) 2019-05-23 US disclosed
US-20190157558-A1 DIAZIRINE CONTAINING ORGANIC ELECTRONIC COMPOSITIONS AND DEVICE THEREOF PROMERUS, LLC (US) 2019-05-23 US disclosed
US-10256409-B2 Diazirine containing organic electronic compositions and device thereof PROMERUS, LLC (US) 2019-04-09 US disclosed
US-10256409-B2 Diazirine containing organic electronic compositions and device thereof PROMERUS, LLC (US) 2019-04-09 US disclosed
EP-3433884-A1 DIAZIRINE CONTAINING ORGANIC ELECTRONIC COMPOSITIONS AND DEVICE THEREOF Promerus, LLC (US) 2019-01-30 EP disclosed
US-20180186747-A1 DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM PROMERUS, LLC (US) 2018-07-05 US disclosed
US-20180186747-A1 DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM PROMERUS, LLC (US) 2018-07-05 US disclosed
US-9938241-B2 Diazirine compounds and compositions derived therefrom PROMERUS, LLC (US) 2018-04-10 US disclosed
US-9938241-B2 Diazirine compounds and compositions derived therefrom PROMERUS, LLC (US) 2018-04-10 US disclosed
US-20170279048-A1 DIAZIRINE CONTAINING ORGANIC ELECTRONIC COMPOSITIONS AND DEVICE THEREOF PROMERUS, LLC (US) 2017-09-28 US disclosed
US-20170279048-A1 DIAZIRINE CONTAINING ORGANIC ELECTRONIC COMPOSITIONS AND DEVICE THEREOF PROMERUS, LLC (US) 2017-09-28 US disclosed
EP-3197881-A1 DIAZIRINE COMPOUNDS AS PHOTOCROSSLINKERS AND PHOTOIMAGEABLE COMPOSITIONS COMPRISING THEM Promerus, LLC (US) 2017-08-02 EP disclosed
WO-2016049123-A1 DIAZIRINE COMPOUNDS AS PHOTOCROSSLINKERS AND PHOTOIMAGEABLE COMPOSITIONS COMPRISING THEM PROMERUS, LLC (US) 2016-03-31 WO disclosed
WO-2016049123-A1 DIAZIRINE COMPOUNDS AS PHOTOCROSSLINKERS AND PHOTOIMAGEABLE COMPOSITIONS COMPRISING THEM PROMERUS, LLC (US) 2016-03-31 WO disclosed
US-20160083352-A1 DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM SUMITOMO BAKELITE CO., LTD. (JP) 2016-03-24 US disclosed
US-20160083352-A1 DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM SUMITOMO BAKELITE CO., LTD. (JP) 2016-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240336599-A1 PHOTOSENSITIVE POLYAMIC ACID AND DIAZIRINE COMPOSITIONS PUF60, FTO, PARN KIF11 2032/4885GABRA1 208/4885GABRB2 353/4885
US-20160083352-A1 DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM RDX, AOX1, ALDH1A2 KIF11 2915/4885GABRA1 1904/4885GABRB2 2144/4885
US-20180186747-A1 DIAZIRINE COMPOUNDS AND COMPOSITIONS DERIVED THEREFROM ZYX, AOX1, RDX KIF11 2025/4885GABRA1 1150/4885GABRB2 1211/4885
US-10303060-B2 Diazirine compounds and compositions derived therefrom ZYX, AOX1, RDX KIF11 2025/4885GABRA1 1150/4885GABRB2 1211/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.