Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.52 |
| ▸ | KDM5A | P29375 | 3/20 | 0.52 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.52 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39557 | 0.98 | LMNA (1.00) | LMNAKDM4EMAPK1NPSR1ALDH1A1 | |
| SCHEMBL30120700 | 0.98 | LMNA (1.00) | LMNAKDM4EMAPK1NPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9081231 | 0.97 | LMNA (0.97) | LMNAKDM4EMAPK1NPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28580096 | 0.97 | LMNA (0.97) | LMNAKDM4EMAPK1NPSR1ALDH1A1 | |
| SCHEMBL29048387 | 0.97 | LMNA (0.97) | LMNAKDM4EMAPK1NPSR1ALDH1A1 | |
| SCHEMBL4353000 | 0.97 | LMNA (0.97) | LMNAKDM4EMAPK1NPSR1ALDH1A1 | |
| SCHEMBL3076842 | 0.97 | LMNA (0.97) | LMNAKDM4EMAPK1NPSR1ALDH1A1 | |
| SCHEMBL3074710 | 0.97 | LMNA (0.97) | LMNAKDM4EMAPK1NPSR1ALDH1A1 | |
| SCHEMBL3079277 | 0.97 | LMNA (0.97) | LMNAKDM4EMAPK1NPSR1ALDH1A1 | |
| SCHEMBL3079376 | 0.97 | LMNA (0.97) | LMNAKDM4EMAPK1NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050176825-A1 | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals | OPTIGENEX, INC. | 2005-08-11 | — | — | US | claimed |
| US-8372449-B2 | Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing antitumor response and treating disorders associated with anti-tumor response in mammals by administering pruified quinic acid and/or carboxy alkyl ester | OPTIGENEX INC. (US) | 2013-02-12 | — | — | US | disclosed |
| US-8372449-B2 | Method for enhancing the DNA repair process, treating disorders associated with the DNA repair process, enhancing antitumor response and treating disorders associated with anti-tumor response in mammals by administering pruified quinic acid and/or carboxy alkyl ester | OPTIGENEX INC. (US) | 2013-02-12 | — | — | US | disclosed |
| US-20110263706-A1 | METHOD FOR ENHANCING THE DNA REPAIR PROCESS, TREATING DISORDERS ASSOCIATED WITH THE DNA REPAIR PROCESS, ENHANCING ANTITUMOR RESPONSE AND TREATING DISORDERS ASSOCIATED WITH ANTI-TUMOR RESPONSE IN MAMMALS BY ADMINISTERING PRUIFIED QUINIC ACID AND/OR CARBOXY ALKYL ESTER | OPTIGENEX, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263706-A1 | METHOD FOR ENHANCING THE DNA REPAIR PROCESS, TREATING DISORDERS ASSOCIATED WITH THE DNA REPAIR PROCESS, ENHANCING ANTITUMOR RESPONSE AND TREATING DISORDERS ASSOCIATED WITH ANTI-TUMOR RESPONSE IN MAMMALS BY ADMINISTERING PRUIFIED QUINIC ACID AND/OR CARBOXY ALKYL ESTER | OPTIGENEX, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| US-7947312-B2 | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals | OPTIGENEX INC. | 2011-05-24 | — | — | US | disclosed |
| US-7947312-B2 | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals | OPTIGENEX INC. | 2011-05-24 | — | — | US | disclosed |
| US-20100227827-A1 | METHOD OF INCREASING TRYPTOPHAN AND NICOTINAMIDE LEVELS IN VIVO | GENETIC HEALTH ENTERPRISES (PTY) LTD. (ZA) | 2010-09-09 | — | — | US | disclosed |
| US-20090298939-A1 | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals | OPTIGENEX, INC. (US) | 2009-12-03 | — | — | US | disclosed |
| US-20090298939-A1 | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals | OPTIGENEX, INC. (US) | 2009-12-03 | — | — | US | disclosed |
| US-20090275656-A1 | Medicinal Compositions of Salts, Chelates and/or Free Acids of Alpha Hydroxyl Organic Acids and Related Processes and Methods | GENETIC HEALTH ENTERPRISES (PTY) LTD. (ZA) | 2009-11-05 | — | — | US | disclosed |
| US-7595064-B2 | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals | OPTIGENEX, INC. | 2009-09-29 | — | — | US | disclosed |
| US-7595064-B2 | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals | OPTIGENEX, INC. | 2009-09-29 | — | — | US | disclosed |
| WO-2008008837-A2 | A METHOD OF INCREASING TRYPTOPHAN AND NICOTINAMIDE LEVELS IN VIVO | LYNPETE TRADING 6 (PTY) LTD. TRADING AS GENETIC HEALTH ENTERPRISES (ZA) | 2008-01-17 | — | — | WO | disclosed |
| EP-1858500-A2 | MEDICINAL COMPOSITIONS OF SALTS, CHELATES AND/OR FREE ACIDS OF ALPHA HYDROXYL ORGANIC ACIDS AND RELATED PROCESSES AND METHODS | Pero, Ronald W. (SE) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006101922-A2 | MEDICINAL COMPOSITIONS OF SALTS, CHELATES AND/OR FREE ACIDS OF ALPHA HYDROXYL ORGANIC ACIDS AND RELATED PROCESSES AND METHODS | PERO RONALD W (SE) | 2006-09-28 | — | — | WO | disclosed |
| US-20050176825-A1 | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals | OPTIGENEX, INC. | 2005-08-11 | — | — | US | disclosed |
| US-20050176825-A1 | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals | OPTIGENEX, INC. | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298939-A1 | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals | PCNA, STING1, IFNG | LMNA 418/4885KDM4E 1591/4885MAPK1 2967/4885 |
| US-20100227827-A1 | METHOD OF INCREASING TRYPTOPHAN AND NICOTINAMIDE LEVELS IN VIVO | NNMT, AADAT, AANAT | LMNA 2527/4885KDM4E 3673/4885MAPK1 3443/4885 |
| US-20050176825-A1 | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals | PCNA, NFATC1, STING1 | LMNA 481/4885KDM4E 1734/4885MAPK1 2775/4885 |
| US-20110263706-A1 | METHOD FOR ENHANCING THE DNA REPAIR PROCESS, TREATING DISORDERS ASSOCIATED WITH THE DNA REPAIR PROCESS, ENHANCING ANTITUMOR RESPONSE AND TREATING DISORDERS ASSOCIATED WITH ANTI-TUMOR RESPONSE IN MAMMALS BY ADMINISTERING PRUIFIED QUINIC ACID AND/OR CARBOXY ALKYL ESTER | STING1, TOP2A, RAD50 | LMNA 630/4885KDM4E 1103/4885MAPK1 2865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.