SCHEMBL17628697

SCHEMBL17628697

COc1cc(NC(=O)Cn2cnc3c2c(=O)n(C)c(=O)n3C)ccc1-c1ccccc1

nearest known ligand 0.69

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.69
RXFP1 Q9HBX9 6/20 0.65
LMNA P02545 1/20 0.64
TP53 P04637 2/20 0.64
USP2 O75604 1/20 0.61
PORCN Q9H237 2/20 0.60
GAA P10253 2/20 0.59
TRPA1 O75762 1/20 0.59
THRB P10828 1/20 0.59
CYP1A2 P05177 1/20 0.59
MAPT P10636 1/20 0.57
HTT P42858 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30128448 1.00 ALOX15 (0.69) ALOX15RXFP1LMNATP53USP2
SCHEMBL17626253 0.89 ALOX15 (0.74) ALOX15RXFP1LMNATP53USP2
SCHEMBL20161798 0.88 RXFP1 (0.73) ALOX15RXFP1LMNATP53USP2
SCHEMBL10114180 0.85 PORCN (0.76) ALOX15RXFP1TP53PORCNTRPA1
SCHEMBL10114131 0.83 RXFP1 (0.75) ALOX15RXFP1LMNATP53GAA
SCHEMBL4533692 0.82 RXFP1 (0.78) ALOX15RXFP1TP53PORCNGAA
SCHEMBL10114488 0.82 ALOX15 (1.00) ALOX15RXFP1LMNATP53USP2
SCHEMBL18166574 0.81 RXFP1 (0.76) ALOX15RXFP1LMNATP53GAA
SCHEMBL17626246 0.81 RXFP1 (0.67) ALOX15RXFP1LMNATP53PORCN
SCHEMBL3795179 0.81 RXFP1 (0.68) ALOX15RXFP1LMNATP53PORCN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12559495-B2 Purine diones as Wnt pathway modulators AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2026-02-24 US disclosed
US-20230366031-A1 KIT FOR IDENTIFYING MALIGNANCY, AND USES THEREOF AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-11-16 US disclosed
US-20230366031-A1 KIT FOR IDENTIFYING MALIGNANCY, AND USES THEREOF AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-11-16 US disclosed
US-20230174533-A1 PURINE DIONES AS WNT PATHWAY MODULATORS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-06-08 US disclosed
US-20230174533-A1 PURINE DIONES AS WNT PATHWAY MODULATORS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-06-08 US disclosed
US-20230174533-A1 PURINE DIONES AS WNT PATHWAY MODULATORS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-06-08 US disclosed
US-11649505-B2 Kit for identifying malignancy, and uses thereof AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-05-16 US disclosed
US-11649505-B2 Kit for identifying malignancy, and uses thereof AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-05-16 US disclosed
US-11555037-B2 Purine diones as Wnt pathway modulators AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-01-17 US disclosed
CN-109776537-B Purine diones as WNT pathway modulators 新加坡科技研究局 2021-12-14 CN disclosed
US-20180170932-A1 PURINE DIONES AS WNT PATHWAY MODULATORS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2018-06-21 US disclosed
US-9926320-B2 Purine diones as Wnt pathway modulators AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2018-03-27 US disclosed
US-9926320-B2 Purine diones as Wnt pathway modulators AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2018-03-27 US disclosed
US-9926320-B2 Purine diones as Wnt pathway modulators AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2018-03-27 US disclosed
US-20170334912-A1 Purine Diones As Wnt Pathway Modulators AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2017-11-23 US disclosed
US-20170334912-A1 Purine Diones As Wnt Pathway Modulators AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2017-11-23 US disclosed
US-20170334912-A1 Purine Diones As Wnt Pathway Modulators AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2017-11-23 US disclosed
US-20160090386-A1 Purine Diones As Wnt Pathway Modulators AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2016-03-31 US disclosed
US-20160090386-A1 Purine Diones As Wnt Pathway Modulators AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2016-03-31 US disclosed
US-20160090386-A1 Purine Diones As Wnt Pathway Modulators AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2016-03-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11649505-B2 Kit for identifying malignancy, and uses thereof KIT, WNT1, WNT3 ALOX15 4493/4885RXFP1 526/4885LMNA 3171/4885
US-20230366031-A1 KIT FOR IDENTIFYING MALIGNANCY, AND USES THEREOF KIT, WNT1, WNT3 ALOX15 4493/4885RXFP1 526/4885LMNA 3171/4885
US-20160090386-A1 Purine Diones As Wnt Pathway Modulators WNT1, WNT3A, CTNNB1 ALOX15 2243/4885RXFP1 1132/4885LMNA 2300/4885
US-20170334912-A1 Purine Diones As Wnt Pathway Modulators WNT1, WNT3A, CTNNB1 ALOX15 2243/4885RXFP1 1132/4885LMNA 2300/4885
US-11555037-B2 Purine diones as Wnt pathway modulators WNT1, WNT3A, WNT3 ALOX15 2390/4885RXFP1 1029/4885LMNA 2103/4885
US-20230174533-A1 PURINE DIONES AS WNT PATHWAY MODULATORS WNT1, WNT3A, WNT3 ALOX15 2390/4885RXFP1 1029/4885LMNA 2103/4885
US-20180170932-A1 PURINE DIONES AS WNT PATHWAY MODULATORS WNT1, WNT3A, CTNNB1 ALOX15 2243/4885RXFP1 1132/4885LMNA 2300/4885
US-12559495-B2 Purine diones as Wnt pathway modulators WNT1, CTNND1, WNT3A ALOX15 3345/4885RXFP1 695/4885LMNA 1338/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.