Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17632036 | 0.81 | USP30 (0.50) | KCNH2USP30CHEK1UCHL1 | |
| SCHEMBL17632261 | 0.79 | HPGDS (0.41) | KCNH2SLC6A3USP30CDK9CHEK1 | |
| SCHEMBL17631943 | 0.78 | USP30 (0.49) | USP30CDK9CHEK1F10 | |
| SCHEMBL17632326 | 0.78 | USP30 (0.49) | USP30CDK9CHEK1F10 | |
| SCHEMBL17631936 | 0.77 | USP30 (0.37) | KCNH2SLC6A3USP30CDK9CHEK1 | |
| SCHEMBL17631923 | 0.76 | UCHL1 (0.50) | KCNH2USP30MAPTALDH1A1NPC1 | |
| SCHEMBL17632095 | 0.76 | USP30 (0.41) | KCNH2USP30CDK9HDAC1HDAC6 | |
| SCHEMBL17631671 | 0.76 | USP30 (0.41) | KCNH2USP30CDK9HDAC1HDAC6 | |
| SCHEMBL17632007 | 0.76 | LIPG (0.41) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL17632335 | 0.75 | USP30 (0.41) | USP30CDK9F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | claimed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | claimed |
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | disclosed |