SCHEMBL1764647

SCHEMBL1764647

COc1ccc(-c2oc3cc(O)c(OC)c(OC)c3c(=O)c2OC)cc1OC

nearest known ligand 0.84

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TUBB4A P04350 5/20 0.84
▸ TUBB P07437 5/20 0.84
▸ TUBA3C P0DPH7 5/20 0.84
▸ TUBA1B P68363 5/20 0.84
▸ TUBA4A P68366 5/20 0.84
▸ TUBB4B P68371 5/20 0.84
▸ TUBB3 Q13509 5/20 0.84
▸ TUBB2A Q13885 5/20 0.84
▸ TUBB8 Q3ZCM7 5/20 0.84
▸ TUBA3E Q6PEY2 5/20 0.84
▸ TUBA1A Q71U36 5/20 0.84
▸ TUBA1C Q9BQE3 5/20 0.84
▸ TUBB6 Q9BUF5 5/20 0.84
▸ TUBB2B Q9BVA1 5/20 0.84
▸ TUBB1 Q9H4B7 5/20 0.84
▸ ABCG2 Q9UNQ0 6/20 0.74
▸ ABCB1 P08183 4/20 0.74
▸ ABCC1 P33527 3/20 0.74
▸ NR0B1 P51843 1/20 0.72
▸ MEN1 O00255 3/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31589366 0.91 TUBB4A (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL31589078 0.91 TUBB4A (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Hexamethoxyflavone SCHEMBL30232628 0.88 MEN1 (0.74) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Hexamethoxyflavone SCHEMBL987569 0.88 MEN1 (0.74) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL21874514 0.87 TUBB4A (0.83) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29750809 0.86 TUBB4A (0.86) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL1252875 0.86 TUBB4A (0.86) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL19347141 0.85 ABCG2 (0.72) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Retusin SCHEMBL1421755 0.85 ABCG2 (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Retusin SCHEMBL29496204 0.85 ABCG2 (1.00) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118304334-A Preparation and application of traditional Chinese medicine fructus rhodomyrti liver protection active ingredient 北京工业大学 2024-07-09 — — CN claimed
US-9669003-B2 Use of flavone and flavanone derivatives in preparation of sedative and hypnotic drugs JIN YONGRI (CN) 2017-06-06 — — US claimed
US-20150196529-A1 USE OF FLAVONE AND FLAVANONE DERIVATIVES IN PREPARATION OF SEDATIVE AND HYPNOTIC DRUGS JIN YONGRI (CN) 2015-07-16 — — US claimed
US-20140039044-A1 Hydroxylated Polymethoxyflavone Compositions WLLGEN, INC. (US) 2014-02-06 — — US claimed
US-20110123653-A1 COMPOSITIONS AND METHODS FOR OPTIMIZING EXERCISE RECOVERY RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2011-05-26 — — US claimed
JP-2009506057-A — — 2009-02-12 — — JP claimed
EP-2010194-A2 HYDROXYLATED POLYMETHOXYFLAVONE COMPOSITIONS Rutgers, The State University of New Jersey (US) 2009-01-07 — — EP claimed
EP-1928480-A2 METHODS FOR MANAGING ADIPOCYTE FAT ACCUMULATION Wellgen, Inc. (US) 2008-06-11 — — EP claimed
EP-1883300-A2 COMPOSITIONS AND METHODS FOR OPTIMIZING EXERCISE RECOVERY Rutgers, The State University of New Jersey (US) 2008-02-06 — — EP claimed
US-20070275106-A1 Hydroxylated polymethoxyflavone compositions WELLGEN, INC. 2007-11-29 — — US claimed
WO-2007109071-A2 HYDROXYLATED POLYMETHOXYFLAVONE COMPOSITIONS RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2007-09-27 — — WO claimed
US-20070088078-A1 Methods for managing adipocyte fat accumulation WELLGEN, INC. 2007-04-19 — — US claimed
US-7201928-B1 Extracts of orange peel for prevention and treatment of cancer RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2007-04-10 — — US claimed
WO-2007024982-A2 METHODS FOR MANAGING ADIPOCYTE FAT ACCUMULATION WELLGEN, INC. (US) 2007-03-01 — — WO claimed
US-20070042972-A1 Compositions and methods for optimizing exercise recovery RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2007-02-22 — — US claimed
WO-2006127996-A2 COMPOSITIONS AND METHODS FOR OPTIMIZING EXERCISE RECOVERY RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2006-11-30 — — WO claimed
US-10165792-B2 Hunger minimized juice fasting system NARASIMHAN SUDARSHAN (US) 2019-01-01 — — US disclosed
US-9669003-B2 Use of flavone and flavanone derivatives in preparation of sedative and hypnotic drugs JIN YONGRI (CN) 2017-06-06 — — US disclosed
US-20070042972-A1 Compositions and methods for optimizing exercise recovery RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2007-02-22 — — US disclosed
WO-2006127996-A2 COMPOSITIONS AND METHODS FOR OPTIMIZING EXERCISE RECOVERY RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2006-11-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070042972-A1 Compositions and methods for optimizing exercise recovery GYS1, PYGM, PRDX5 TUBB4A 4627/4885TUBB 4613/4885TUBA3C 4421/4885
US-20070088078-A1 Methods for managing adipocyte fat accumulation FABP4, PLIN5, PLIN3 TUBB4A 2496/4885TUBB 3343/4885TUBA3C 2815/4885
US-20070275106-A1 Hydroxylated polymethoxyflavone compositions PLIN5, FANCF, COXFA4 TUBB4A 4260/4885TUBB 3598/4885TUBA3C 3993/4885
US-20110123653-A1 COMPOSITIONS AND METHODS FOR OPTIMIZING EXERCISE RECOVERY GYS1, PYGM, PRDX5 TUBB4A 4627/4885TUBB 4613/4885TUBA3C 4421/4885
US-20150196529-A1 USE OF FLAVONE AND FLAVANONE DERIVATIVES IN PREPARATION OF SEDATIVE AND HYPNOTIC DRUGS CYP2D6, GATAD2A, CYP3A43 TUBB4A 960/4885TUBB 533/4885TUBA3C 254/4885
US-20140039044-A1 Hydroxylated Polymethoxyflavone Compositions PLIN5, FANCF, COXFA4 TUBB4A 4260/4885TUBB 3598/4885TUBA3C 3993/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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