Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.56 |
| ▸ | TSHR | P16473 | 7/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid Ethyl Ester SCHEMBL11043394 | 0.93 | HCAR2 (0.46) | HCAR2TSHRHPGDALDH1A1HSD17B10 | |
| Ethyl Fumarate SCHEMBL9678685 | 0.92 | HCAR2 (0.69) | HCAR2ALDH1A1HSD17B10LMNANPSR1 | |
| Ethyl Fumarate SCHEMBL9678697 | 0.92 | HCAR2 (0.69) | HCAR2ALDH1A1HSD17B10LMNANPSR1 | |
| Acrylic Acid Ethyl Ester SCHEMBL8060405 | 0.91 | TSHR (0.47) | HCAR2TSHRHPGDALDH1A1HSD17B10 | |
| Ethyl Fumarate SCHEMBL10900161 | 0.89 | HCAR2 (0.65) | HCAR2ALDH1A1HSD17B10LMNANPSR1 | |
| Acrylic Acid Ethyl Ester SCHEMBL28542637 | 0.88 | TSHR (0.44) | HCAR2TSHRHPGDALDH1A1HSD17B10 | |
| Maleic Acid SCHEMBL5400251 | 0.88 | HCAR2 (0.58) | HCAR2TSHRHPGDALDH1A1LMNA | |
| Fumaric Acid SCHEMBL8925070 | 0.88 | HCAR2 (0.72) | HCAR2TSHRHPGDALDH1A1HSD17B10 | |
| Fumaric Acid SCHEMBL10717454 | 0.88 | HCAR2 (0.72) | HCAR2TSHRHPGDALDH1A1HSD17B10 | |
| Maleic Acid SCHEMBL8772268 | 0.88 | HCAR2 (0.72) | HCAR2TSHRHPGDALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106103359-A | Compositions and methods for fouling control in regulated vaporization systems | 索理思科技开曼公司 | 2016-11-09 | — | — | CN | claimed |
| US-8530403-B2 | Solidification matrix using a maleic-containing terpolymer binding agent | ECOLAB USA INC. (US) | 2013-09-10 | — | — | US | claimed |
| US-10737221-B2 | Scale inhibitor for reverse osmosis membranes and reverse osmosis membrane treatment method | KURITA WATER INDUSTRIES LTD. (JP) | 2020-08-11 | — | — | US | disclosed |
| US-20190030489-A1 | SCALE INHIBITOR FOR REVERSE OSMOSIS MEMBRANES AND REVERSE OSMOSIS MEMBRANE TREATMENT METHOD | KURITA WATER INDUSTRIES LTD. (JP) | 2019-01-31 | — | — | US | disclosed |
| US-20160046515-A1 | METHOD FOR PREVENTING SCALE DEPOSITION AND SCALE INHIBITOR | KURITA WATER INDUSTRIES LTD. (JP) | 2016-02-18 | — | — | US | disclosed |
| US-8530403-B2 | Solidification matrix using a maleic-containing terpolymer binding agent | ECOLAB USA INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-20110124546-A1 | SOLIDIFICATION MATRIX USING A MALEIC-CONTAINING TERPOLYMER BINDING AGENT | ECOLAB INC. (US) | 2011-05-26 | — | — | US | disclosed |
| WO-2011061654-A2 | SOLIDIFICATION MATRIX USING A MALEIC-CONTAINING TERPOLYMER BINDING AGENT | ECOLAB INC. (US) | 2011-05-26 | — | — | WO | disclosed |