Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.46 |
| ▸ | ABAT | P80404 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.46 |
| ▸ | KRAS | P01116 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29803132 | 1.00 | TUBB1 (0.50) | TUBB1ALDH1A1TSHRHPGDTRIM24 | |
| SCHEMBL2306018 | 0.88 | TUBB1 (0.47) | TUBB1ALDH1A1TSHRHPGDTRIM24 | |
| SCHEMBL16619850 | 0.86 | ALDH1A1 (0.59) | TUBB1ALDH1A1TSHRHPGDTRIM24 | |
| SCHEMBL96635 | 0.86 | ALDH1A1 (0.59) | TUBB1ALDH1A1TSHRHPGDTRIM24 | |
| SCHEMBL12493025 | 0.84 | ALDH1A1 (0.43) | TUBB1ALDH1A1TSHRHPGDTRIM24 | |
| Hydrochloric Acid SCHEMBL23711567 | 0.84 | ALDH1A1 (0.57) | TUBB1ALDH1A1TSHRHPGDTRIM24 | |
| SCHEMBL29411737 | 0.82 | ALDH1A1 (0.52) | TUBB1ALDH1A1TSHRHPGDTRIM24 | |
| SCHEMBL5200065 | 0.82 | ALDH1A1 (0.52) | TUBB1ALDH1A1TSHRHPGDTRIM24 | |
| SCHEMBL16680535 | 0.82 | FDPS (0.50) | TUBB1ALDH1A1TSHRHPGDTDP1 | |
| SCHEMBL13512685 | 0.81 | ALDH1A1 (0.50) | TUBB1ALDH1A1TSHRHPGDTRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12540144-B2 | Rapafucin derivative compounds and methods of use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2026-02-03 | — | — | US | disclosed |
| US-20240239810-A1 | RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF | THE JOHNS HOPKINS UNIVERSITY | 2024-07-18 | — | — | US | disclosed |
| US-11945827-B2 | Rapafucin derivative compounds and methods of use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2024-04-02 | — | — | US | disclosed |
| CN-114539249-B | Podophyllotoxin derivative tubulin inhibitor, and preparation method and medical application thereof | 中国药科大学 | 2024-01-26 | — | — | CN | disclosed |
| US-20230000996-A1 | RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF | THE JOHNS HOPKINS UNIVERSITY | 2023-01-05 | — | — | US | disclosed |
| US-20230000996-A1 | RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF | THE JOHNS HOPKINS UNIVERSITY | 2023-01-05 | — | — | US | disclosed |
| US-20220363692-A1 | RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF | THE JOHNS HOPKINS UNIVERSITY | 2022-11-17 | — | — | US | disclosed |
| EP-4037702-A1 | RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF | The Johns Hopkins University (US) | 2022-08-10 | — | — | EP | disclosed |
| CN-114539249-A | Podophyllotoxin derivative tubulin inhibitor and preparation method and medical application thereof | 中国药科大学 | 2022-05-27 | — | — | CN | disclosed |
| US-20220119400-A1 | QUINAZOLINE AND INDOLE COMPOUNDS TO TREAT MEDICAL DISORDERS | ACHILLION PHARMACEUTICALS INC (US) | 2022-04-21 | — | — | US | disclosed |
| US-20110104055-A1 | SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES | PROTEOTECH INC. | 2011-05-05 | — | — | US | disclosed |
| US-7507851-B2 | Halocombstatins and methods of synthesis thereof | ARIZONA BOARD OF REGENTS, A STATE CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2009-03-24 | — | — | US | disclosed |
| US-20090060838-A1 | SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES | PROTEOTECH INC. | 2009-03-05 | — | — | US | disclosed |
| US-20080119649-A1 | HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY | 2008-05-22 | — | — | US | disclosed |
| US-20070167412-A1 | HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF | ARIZONA BOARD OF REGENTS (US) | 2007-07-19 | — | — | US | disclosed |
| EP-1802560-A2 | HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF | Arizona Board Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University (US) | 2007-07-04 | — | — | EP | disclosed |
| US-7223747-B2 | Halocombstatins and methods of synthesis thereof | ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2007-05-29 | — | — | US | disclosed |
| US-7223747-B2 | Halocombstatins and methods of synthesis thereof | ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2007-05-29 | — | — | US | disclosed |
| WO-2006036743-A2 | HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2006-04-06 | — | — | WO | disclosed |
| US-20050176688-A1 | Halocombstatins and methods of synthesis thereof | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119649-A1 | HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF | TUBB3, TUBB8B, TUBB8 | TUBB1 8/4885ALDH1A1 4790/4885TSHR 3150/4885 |
| US-20220363692-A1 | RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF | RICTOR, FKBP14, MTOR | TUBB1 2480/4885ALDH1A1 4678/4885TSHR 3853/4885 |
| US-20070167412-A1 | HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF | TUBB3, TUBB8B, TUBB8 | TUBB1 8/4885ALDH1A1 4790/4885TSHR 3150/4885 |
| US-20230000996-A1 | RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF | RICTOR, FKBP14, MTOR | TUBB1 2480/4885ALDH1A1 4678/4885TSHR 3853/4885 |
| US-20220119400-A1 | QUINAZOLINE AND INDOLE COMPOUNDS TO TREAT MEDICAL DISORDERS | CFB, TFPI, MAOB | TUBB1 1253/4885ALDH1A1 3311/4885TSHR 2180/4885 |
| US-20090060838-A1 | SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES | IAPP, SNCA, BACE2 | TUBB1 781/4885ALDH1A1 2612/4885TSHR 4003/4885 |
| US-20110104055-A1 | SUBSTITUTED N-ARYL BENZAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES | IAPP, SNCA, BACE2 | TUBB1 723/4885ALDH1A1 2495/4885TSHR 4061/4885 |
| US-11945827-B2 | Rapafucin derivative compounds and methods of use thereof | RICTOR, FKBP14, MTOR | TUBB1 2480/4885ALDH1A1 4678/4885TSHR 3853/4885 |
| US-12540144-B2 | Rapafucin derivative compounds and methods of use thereof | RICTOR, CHP1, FKBP8 | TUBB1 1945/4885ALDH1A1 4764/4885TSHR 2134/4885 |
| US-20050176688-A1 | Halocombstatins and methods of synthesis thereof | TUBB3, TUBB8B, TUBB8 | TUBB1 8/4885ALDH1A1 4790/4885TSHR 3150/4885 |
| US-20240239810-A1 | RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF | RICTOR, MTOR, FKBP14 | TUBB1 3016/4885ALDH1A1 4631/4885TSHR 4022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.