SCHEMBL1766786

SCHEMBL1766786

O=C(Nc1c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc1C(F)(F)F)c1cccc([N+](=O)[O-])c1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX1 P51575 2/20 0.46
KCNMA1 Q12791 2/20 0.41
KMT2A Q03164 6/20 0.40
MEN1 O00255 5/20 0.40
RAB9A P51151 1/20 0.40
MAPT P10636 2/20 0.39
LMNA P02545 2/20 0.39
CYP2C9 P11712 2/20 0.38
DHODH Q02127 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.37
PKM P14618 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C19 P33261 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
TRPV1 Q8NER1 1/20 0.37
ALDH1A1 P00352 1/20 0.37
MDM2 Q00987 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29615050 1.00 P2RX1 (0.46) P2RX1KCNMA1KMT2AMEN1RAB9A
SCHEMBL1766978 0.93 P2RX1 (0.43) P2RX1KCNMA1KMT2AMEN1RAB9A
SCHEMBL1767290 0.93 P2RX1 (0.47) P2RX1KCNMA1KMT2AMEN1RAB9A
SCHEMBL1767201 0.90 P2RX1 (0.44) P2RX1KCNMA1KMT2AMEN1RAB9A
SCHEMBL12439877 0.89 P2RX1 (0.47) P2RX1KCNMA1KMT2AMEN1RAB9A
SCHEMBL31175825 0.89 KMT2A (0.47) P2RX1KCNMA1KMT2AMEN1RAB9A
SCHEMBL29257321 0.89 P2RX1 (0.47) P2RX1KCNMA1KMT2AMEN1RAB9A
SCHEMBL1766569 0.88 P2RX1 (0.46) P2RX1KCNMA1KMT2AMEN1MAPT
SCHEMBL22497571 0.88 P2RX1 (0.43) P2RX1KCNMA1KMT2AMEN1RAB9A
SCHEMBL16155805 0.88 P2RX1 (0.43) P2RX1KCNMA1KMT2AMEN1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114805294-B Heteroaryl substituted meta-diamide compound or salt acceptable as pesticide, composition and application thereof 海利尔药业集团股份有限公司 2024-05-31 CN disclosed
US-11891371-B2 Piperonylic acid derivative and preparation and application thereof Shenyang Sinochem Agrochemicals R&D Co., LTD (CN) 2024-02-06 US disclosed
CN-117466813-A Meta-aminobenzoic acid bisamide compound and intermediate thereof 湖南化工研究院有限公司 2024-01-30 CN disclosed
CN-114394912-B Meta-diamide compound or salt and composition acceptable by pesticide and application thereof 海利尔药业集团股份有限公司 2024-01-26 CN disclosed
CN-115304510-B Aryl substituted meta-diamide compound or salt and composition thereof acceptable as pesticides and application thereof 海利尔药业集团股份有限公司 2024-01-02 CN disclosed
WO-2023051261-A1 IMINE COMPOUND AND USE THEREOF 沈阳中化农药化工研发有限公司 2023-04-06 WO disclosed
CN-115872901-A Imine compound and application thereof 沈阳中化农药化工研发有限公司 2023-03-31 CN disclosed
CN-115304510-A Aryl-substituted m-diamide compound or salt thereof acceptable as pesticide, composition and application thereof 海利尔药业集团股份有限公司 2022-11-08 CN disclosed
CN-114805294-A Heteroaryl-substituted m-diamide compound or salt thereof as pesticide acceptable, composition and application thereof 海利尔药业集团股份有限公司 2022-07-29 CN disclosed
CN-110028423-B Meta-diamide compound and preparation method and application thereof 上海晓明检测技术服务有限公司 2022-07-01 CN disclosed
US-20130310459-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2013-11-21 US disclosed
US-20130231392-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS ARGO, INC. (JP) 2013-09-05 US disclosed
EP-2529620-A1 COMPOSITION FOR CONTROL OF ANIMAL PARASITES, AND METHOD FOR CONTROL OF ANIMAL PARASITES Mitsui Chemicals Agro, Inc. (JP) 2012-12-05 EP disclosed
CN-102740695-A Composition for exterminating animal parasites and method for exterminating animal parasites MITSUI CHEMICALS AGRO INC 2012-10-17 CN disclosed
US-20110201687-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2011-08-18 US disclosed
CN-102119143-A Amide derivative, pest control agent containing the same, and method of using the pest control agent MITSUI CHEMICALS AGRO INC 2011-07-06 CN disclosed
CN-102112437-A Amide derivative, pest control agent containing same, and pest control method MITSUI CHEMICALS AGRO INC 2011-06-29 CN disclosed
US-20110136878-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND PEST CONTROLLING METHOD Mitsui Chemicals Agro., Inc. (JP) 2011-06-09 US disclosed
EP-2325165-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE AND PEST CONTROLLING METHOD Mitsui Chemicals Agro, Inc. (JP) 2011-05-25 EP disclosed
EP-2319830-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE AND USE OF THE PEST CONTROL AGENT Mitsui Chemicals Agro, Inc. (JP) 2011-05-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110136878-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND PEST CONTROLLING METHOD L3MBTL1, L3MBTL4, L3MBTL3 P2RX1 4192/4885KCNMA1 844/4885KMT2A 134/4885
US-11891371-B2 Piperonylic acid derivative and preparation and application thereof CYP51A1, DDT, PIR P2RX1 1030/4885KCNMA1 956/4885KMT2A 2382/4885
US-20130310459-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-0, H1-4 P2RX1 3567/4885KCNMA1 802/4885KMT2A 262/4885
US-20110201687-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-4, H1-0 P2RX1 3026/4885KCNMA1 904/4885KMT2A 333/4885
US-20130231392-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-0, H1-4 P2RX1 3567/4885KCNMA1 802/4885KMT2A 262/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.