Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.30 |
| ▸ | BCL6 | P41182 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | USP1 | O94782 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182715 | 0.89 | POLB (0.39) | NPC1MAPTIDH1IDH2PRMT6 | |
| SCHEMBL17553650 | 0.86 | NPC1 (0.33) | NPC1MAPTIDH1IDH2PRMT6 | |
| SCHEMBL17640652 | 0.83 | PDE2A (0.33) | IDH1PDE10A | |
| SCHEMBL17696230 | 0.82 | ELANE (0.31) | — | |
| SCHEMBL17688763 | 0.82 | PTGS2 (0.32) | USP1 | |
| SCHEMBL20567951 | 0.82 | POLB (0.32) | USP1 | |
| SCHEMBL19240683 | 0.82 | NPC1 (0.32) | NPC1MAPTIDH1IDH2PRMT6 | |
| SCHEMBL22912032 | 0.81 | LRRK2 (0.36) | USP1 | |
| SCHEMBL19366987 | 0.80 | CNR2 (0.31) | — | |
| SCHEMBL17696196 | 0.80 | PTGS2 (0.36) | USP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10544148-B2 | Pesticidally active tetracyclic heterocyclic derivatives with sulphur containing substituents | SYNGENTA PARTICIPATIONS AG (CH) | 2020-01-28 | — | — | US | disclosed |
| US-10544148-B2 | Pesticidally active tetracyclic heterocyclic derivatives with sulphur containing substituents | SYNGENTA PARTICIPATIONS AG (CH) | 2020-01-28 | — | — | US | disclosed |
| EP-3207044-B1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-07-25 | — | — | EP | disclosed |
| US-20170240554-A1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-08-24 | — | — | US | disclosed |
| US-20170240554-A1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-08-24 | — | — | US | disclosed |
| US-20170240554-A1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2017-08-24 | — | — | US | disclosed |
| WO-2016059145-A1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | SYNGENTA PARTICIPATIONS AG (CH) | 2016-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544148-B2 | Pesticidally active tetracyclic heterocyclic derivatives with sulphur containing substituents | DDT, ACHE, TST | NPC1 2440/4885MAPT 1046/4885IDH1 238/4885 |
| US-20170240554-A1 | PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS | DDT, ACHE, TST | NPC1 2440/4885MAPT 1046/4885IDH1 238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.