SCHEMBL177343

SCHEMBL177343

Nc1ccccc1CO[C]=O

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FDPS P14324 1/20 0.38
CYP3A4 P08684 1/20 0.36
ALOX15 P16050 1/20 0.36
CASP1 P29466 1/20 0.36
CASP7 P55210 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
AR P10275 1/20 0.33
IDO1 P14902 10/20 0.32
ALDH1A1 P00352 4/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
HSD17B10 Q99714 1/20 0.32
POLB P06746 1/20 0.31
ADRA2B P18089 1/20 0.31
PTGS1 P23219 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
GAA P10253 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5539858 0.80 FDPS (0.36) FDPSCYP3A4ALOX15CASP1CASP7
SCHEMBL5984175 0.77 GABRA1 (0.41) IDO1L3MBTL1
SCHEMBL98042 0.75 IDO1 (0.55) IDO1ALDH1A1L3MBTL1
SCHEMBL28923 0.75 IDO1 (0.55) SMN1; SMN2IDO1ALDH1A1POLB
SCHEMBL5519683 0.75 IDO1 (0.55) IDO1HSD17B10
SCHEMBL98917 0.75 IDO1 (0.55) SMN1; SMN2IDO1L3MBTL1
SCHEMBL133171 0.75 MAOB (0.45) ALDH1A1ADRA2BPTGS1
SCHEMBL1937871 0.75 IDO1 (0.55) IDO1
SCHEMBL541805 0.75 ALOX15 (0.45) FDPSCYP3A4ALOX15CASP1CASP7
SCHEMBL15740590 0.73 MEN1 (0.44) CYP3A4ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 865 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024133763-A2 ALPP-SPECIFIC VARIANT ANTIGEN BINDING MOLECULES ALMAC DISCOVERY LIMITED (GB) 2024-06-27 WO claimed
US-20240082409-A1 Modified peptide ligands for stable delivery of highly potent payloads to tumors: Method of making and using same LAMHARZI NAJIB (US) 2024-03-14 US claimed
WO-2024054821-A2 TISSUE FACTOR ANTIBODY-DRUG CONJUGATES AND USES THEREOF EXELIXIS, INC. (US) 2024-03-14 WO claimed
WO-2024028258-A1 CONJUGATES OF PSMA-BINDING MOIETIES WITH CYTOTOXIC AGENTS PHILOCHEM AG (CH) 2024-02-08 WO claimed
US-20240000963-A1 HYDROPHILIC LINKERS AND CONJUGATES THEREOF GLYKOS FINLAND OY (FI) 2024-01-04 US claimed
EP-4294453-A1 LINKER-PAYLOADS AND CONJUGATES THEREOF Glykos Finland Oy (FI) 2023-12-27 EP claimed
EP-4274583-A2 METHODS AND COMPOUNDS FOR TREATING FRIEDREICH'S ATAXIA Design Therapeutics, Inc. (US) 2023-11-15 EP claimed
EP-4262878-A1 FAP-ACTIVATED RADIOTHERANOSTICS, AND USES RELATED THERETO TRUSTEES OF TUFTS COLLEGE (US) 2023-10-25 EP claimed
EP-4262987-A1 ROR1-SPECIFIC VARIANT ANTIGEN BINDING MOLECULES Almac Discovery Limited (GB) 2023-10-25 EP claimed
CN-116806157-A Linker-payload and conjugates thereof 芬兰吉利科斯有限公司 2023-09-26 CN claimed
WO-2009012268-A1 ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE GENENTECH, INC. (US) 2009-01-22 WO claimed
EP-1996625-A1 ANTI-TAT226 ANTIBODIES AND IMMUNOCONJUGATES Genentech, Inc. (US) 2008-12-03 EP claimed
EP-1942944-A2 MACROCYCLIC DEPSIPEPTIDE ANTIBODY-DRUG CONJUGATES AND METHODS Genentech, Inc. (US) 2008-07-16 EP claimed
EP-1912677-A2 PSMA ANTIBODY-DRUG CONJUGATES Psma Development Company, L.L.C. (US) 2008-04-23 EP claimed
WO-2007140371-A2 ANTIBODIES AND IMMUNOCONJUGATES AND USES THEREFOR GENENTECH, INC. (US) 2007-12-06 WO claimed
WO-2007109567-A1 ANTI-TAT226 ANTIBODIES AND IMMUNOCONJUGATES GENENTECH, INC. (US) 2007-09-27 WO claimed
WO-2007100385-A2 MACROCYCLIC DEPSIPEPTIDE ANTIBODY-DRUG CONJUGATES AND METHODS GENENTECH, INC. (US) 2007-09-07 WO claimed
WO-2007002222-A2 PSMA ANTIBODY-DRUG CONJUGATES PSMA DEVELOPMENT COMPANY, LLC (US) 2007-01-04 WO claimed
EP-1560599-A1 PRODRUGS BUILT AS MULTIPLE SELF-ELIMINATION-RELEASE SPACERS Syntarga B.V. (NL) 2005-08-10 EP claimed
WO-2004043493-A1 PRODRUGS BUILT AS MULTIPLE SELF-ELIMINATION-RELEASE SPACERS SYNTARGA B.V. (NL) 2004-05-27 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240000963-A1 HYDROPHILIC LINKERS AND CONJUGATES THEREOF CD44, FOLR2, SLCO2B1 FDPS 3679/4885CYP3A4 2715/4885ALOX15 2830/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.