Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.64 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.64 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.63 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | IDO1 | P14902 | 1/20 | 0.59 |
| ▸ | CNR2 | P34972 | 1/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.56 |
| ▸ | ALPL | P05186 | 1/20 | 0.54 |
| ▸ | DDX3X | O00571 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.50 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17737442 | 0.88 | GLO1 (0.62) | SLC40A1GLO1KEAP1NFE2L2GAA | |
| SCHEMBL17737451 | 0.85 | IDO1 (0.56) | SLC40A1GLO1KEAP1NFE2L2GAA | |
| SCHEMBL17737448 | 0.85 | KEAP1 (0.62) | KEAP1NFE2L2IDO1CNR2DDX3X | |
| SCHEMBL17737675 | 0.84 | IDO1 (0.63) | SLC40A1GLO1GAAIDO1CNR2 | |
| SCHEMBL17737767 | 0.83 | IDO1 (0.67) | GLO1IDO1CNR2DDX3XLMNA | |
| SCHEMBL19852956 | 0.82 | RECQL (0.69) | SLC40A1GLO1IDO1DDX3XALDH1A1 | |
| SCHEMBL17737365 | 0.81 | IDO1 (0.63) | SLC40A1GLO1IDO1CNR2DDX3X | |
| SCHEMBL19852954 | 0.79 | IDO1 (0.62) | SLC40A1KEAP1NFE2L2IDO1DDX3X | |
| SCHEMBL17737441 | 0.79 | IDO1 (0.62) | SLC40A1GLO1KEAP1IDO1CNR2 | |
| SCHEMBL11973668 | 0.78 | SLC40A1 (1.00) | SLC40A1GLO1LMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3215155-B1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD (GB) | 2020-10-14 | — | — | EP | disclosed |
| US-10287252-B2 | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase | IOMET PHARMA LTD. (GB) | 2019-05-14 | — | — | US | disclosed |
| US-20180037553-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD. (GB) | 2018-02-08 | — | — | US | disclosed |
| WO-2016071283-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD (GB) | 2016-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287252-B2 | Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase | TDO2, IDO2, IDO1 | SLC40A1 2382/4885GLO1 936/4885KEAP1 1682/4885 |
| US-20180037553-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | TDO2, IDO2, IDO1 | SLC40A1 2382/4885GLO1 936/4885KEAP1 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.