Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | AGXT | P21549 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9577155 | 0.92 | SMN1; SMN2 (0.41) | SMN1; SMN2TSHRIDO1SLC1A3SLC1A2 | |
| SCHEMBL9497399 | 0.92 | SMN1; SMN2 (0.41) | SMN1; SMN2TSHRIDO1SLC1A3SLC1A2 | |
| SCHEMBL16370105 | 0.89 | SLC1A3 (0.39) | SMN1; SMN2TSHRIDO1SLC1A3SLC1A2 | |
| SCHEMBL22490406 | 0.89 | MEN1 (0.40) | SMN1; SMN2TSHRIDO1SLC1A3SLC1A2 | |
| SCHEMBL15602691 | 0.88 | SMN1; SMN2 (0.38) | SMN1; SMN2TSHRIDO1SLC1A3SLC1A2 | |
| SCHEMBL1777446 | 0.85 | TSHR (0.47) | SMN1; SMN2TSHRIDO1CYP2C19TDP1 | |
| SCHEMBL11514285 | 0.85 | LMNA (0.39) | SMN1; SMN2TSHRCYP2C19MEN1CYP1A2 | |
| SCHEMBL30876749 | 0.85 | TDP1 (0.39) | SMN1; SMN2TSHRSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL14393103 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2TSHRIDO1SLC1A3SLC1A2 | |
| SCHEMBL16177752 | 0.84 | BCHE (0.39) | SMN1; SMN2TSHRTDP1RCE1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3727355-A1 | COMPOUNDS AND THEIR USE IN TREATING CANCER | AstraZeneca AB (SE) | 2020-10-28 | — | — | EP | disclosed |
| CN-111491623-A | Compounds and their use in the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2020-08-04 | — | — | CN | disclosed |
| US-20190194190-A1 | Compounds and Their Use in Treating Cancer | ASTRAZENECA PHARMACEUTICALS LP | 2019-06-27 | — | — | US | disclosed |
| US-20190194190-A1 | Compounds and Their Use in Treating Cancer | ASTRAZENECA PHARMACEUTICALS LP | 2019-06-27 | — | — | US | disclosed |
| US-20160031845-A1 | IN-SITU GENERATION OF RUTHENIUM CATALYSTS FOR OLEFIN METATHESIS | EVONIK DEGUSSA GMBH (DE) | 2016-02-04 | — | — | US | disclosed |
| US-20150322079-A1 | LOW CATALYST LOADING IN METATHESIS REACTIONS | EVONIK INDUSTRIES AG (DE) | 2015-11-12 | — | — | US | disclosed |
| US-20150322079-A1 | LOW CATALYST LOADING IN METATHESIS REACTIONS | EVONIK INDUSTRIES AG (DE) | 2015-11-12 | — | — | US | disclosed |
| EP-2711351-A1 | Low catalyst loading in metathesis reactions | Evonik Industries AG (DE) | 2014-03-26 | — | — | EP | disclosed |
| US-8227635-B2 | Apparatus and method for carrying out multiple reactions | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2012-07-24 | — | — | US | disclosed |
| US-7943715-B2 | Polymerization of 1,6-heptadiene in the presence of a catalyst formed by contacting a transition metal with a diimino aluminum or boron compound, giving a polymer structure of alternating ethylene and cyclopentene; superior balance between a heat resistance and workability | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-05-17 | — | — | US | disclosed |
| US-20090299102-A1 | APPARATUS AND METHOD FOR CARRYING OUT MULTIPLE REACTIONS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2009-12-03 | — | — | US | disclosed |
| US-20080221286-A1 | DIENE POLYMER AND PROCESS FOR PRODUCING THE SAME | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2008-09-11 | — | — | US | disclosed |
| CN-101255211-A | Diene polymer and process for producing the same | SUMITOMO CHEMICAL CO (JP) | 2008-09-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090299102-A1 | APPARATUS AND METHOD FOR CARRYING OUT MULTIPLE REACTIONS | DDO, APEX1, MMAB | SMN1; SMN2 3560/4885TSHR 2913/4885IDO1 849/4885 |
| US-20160031845-A1 | IN-SITU GENERATION OF RUTHENIUM CATALYSTS FOR OLEFIN METATHESIS | LOXL2, MLX, MCOLN2 | SMN1; SMN2 4316/4885TSHR 3370/4885IDO1 412/4885 |
| US-20150322079-A1 | LOW CATALYST LOADING IN METATHESIS REACTIONS | APEX1, PMS2, MAX | SMN1; SMN2 3506/4885TSHR 4795/4885IDO1 1817/4885 |
| US-20190194190-A1 | Compounds and Their Use in Treating Cancer | F12, CCNY, CCNE1 | SMN1; SMN2 1942/4885TSHR 687/4885IDO1 3825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.