SCHEMBL177721

SCHEMBL177721

Nc1ccc(Oc2ccc(Cl)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 2/20 1.00
▸ MAOB P27338 1/20 1.00
▸ ALDH1A1 P00352 6/20 0.74
▸ TDP1 Q9NUW8 2/20 0.74
▸ CYP3A4 P08684 1/20 0.74
▸ TSHR P16473 1/20 0.74
▸ MAPT P10636 5/20 0.58
▸ TEAD4 Q15561 1/20 0.58
▸ MEN1 O00255 4/20 0.56
▸ KMT2A Q03164 4/20 0.56
▸ SMN1; SMN2 Q16637 3/20 0.56
▸ POLB P06746 1/20 0.56
▸ MITF O75030 1/20 0.56
▸ GAA P10253 1/20 0.56
▸ GFER P55789 1/20 0.56
▸ NLRP1 Q9C000 1/20 0.56
▸ NOD2 Q9HC29 1/20 0.56
▸ HPGD P15428 2/20 0.52
▸ NPC1 O15118 2/20 0.52
▸ RAB9A P51151 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11401887 0.97 MAOA (0.95) MAOAMAOBALDH1A1TDP1CYP3A4
SCHEMBL4983708 0.93 MAOA (0.86) MAOAMAOBALDH1A1TDP1CYP3A4
SCHEMBL10576066 0.86 ALDH1A1 (1.00) MAOAMAOBALDH1A1TDP1CYP3A4
SCHEMBL65211 0.86 ALDH1A1 (1.00) MAOAMAOBALDH1A1TDP1CYP3A4
SCHEMBL202864 0.86 ALDH1A1 (1.00) MAOAMAOBALDH1A1TDP1CYP3A4
SCHEMBL4446167 0.86 ALDH1A1 (1.00) MAOAMAOBALDH1A1TDP1CYP3A4
SCHEMBL4455485 0.86 ALDH1A1 (1.00) MAOAMAOBALDH1A1TDP1CYP3A4
SCHEMBL1331804 0.86 ALDH1A1 (1.00) MAOAMAOBALDH1A1TDP1CYP3A4
SCHEMBL2013073 0.86 ALDH1A1 (1.00) MAOAMAOBALDH1A1TDP1CYP3A4
SCHEMBL41849 0.86 ALDH1A1 (1.00) MAOAMAOBALDH1A1TDP1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 418 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119100995-A Acetohydroxyacid synthase inhibitors, process for their preparation and their use as herbicides 浙江大学 2024-12-10 — — CN claimed
CN-116789574-B Preparation method and application of camphorsulfonamide compound containing diphenyl ether group 南京林业大学 2024-07-30 — — CN claimed
EP-3405453-B1 A METHOD FOR PREPARING POLY(CARBONATE-ETH ERIMIDE) COMPOUND PTT GLOBAL CHEMICAL PUBLIC CO LTD (TH) 2024-05-29 — — EP claimed
CN-113880765-B 4- (1H-pyrazol-1-yl) biphenyl formamide compound containing diphenyl ether group and application thereof 南京林业大学 2023-04-28 — — CN claimed
CN-108884032-B Method for preparing poly (carbonate-etherimide) compounds PTT全球化学股份有限公司 2021-10-15 — — CN claimed
US-10759904-B2 Method for preparing poly(carbonate-etherimide) compound PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITED (TH) 2020-09-01 — — US claimed
US-20190202980-A1 METHOD FOR PREPARING POLY(CARBONATE-ETHERIMIDE) COMPOUND PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITED (TH) 2019-07-04 — — US claimed
EP-3405453-A2 A METHOD FOR PREPARING POLY(CARBONATE-ETH ERIMIDE) COMPOUND PTT Global Chemical Public Company Limited (TH) 2018-11-28 — — EP claimed
CN-108884032-A The method for preparing poly- (carbonic ester-etherimide) compound PTT全球化学股份有限公司 2018-11-23 — — CN claimed
EP-1773768-B1 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS EXELIXIS INC (US) 2018-08-22 — — EP claimed
US-20040002521-A1 Cyclopropanecarboxylic acid amide compound and pharmaceutical use thereof AJINOMOTO CO. INC 2004-01-01 — — US claimed
EP-3797991-B1 PREPREG AND PRODUCTION METHOD THEREFOR, SLIT TAPE PREPREG, CARBON FIBER-REINFORCED COMPOSITE MATERIAL TORAY INDUSTRIES (JP) 2025-10-29 — — EP disclosed
US-12448510-B2 Prepreg, method for producing same, and slit tape prepreg TORAY INDUSTRIES, INC. (JP) 2025-10-21 — — US disclosed
WO-2025217513-A1 ACTIVATION OF PLCG2 AS A THERAPEUTIC STRATEGY FOR THE TREATMENT OF ALZHEIMER'S DISEASE THE TRUSTEES OF INDIANA UNIVERSITY (US) 2025-10-16 — — WO disclosed
US-20250296935-A1 Diamine Derivatives as Inhibitors of Leukotriene A4 Hydrolase CELLTAXIS LLC (US) 2025-09-25 — — US disclosed
US-3979378-A Water-soluble azo dyes having a substituted 2-hydroxypyridone (6) coupling component BADISCHE ANILIN- & SODA-FABRIK AKTIENGESELLSCHAFT (DT) 1976-09-07 — — US disclosed
US-3971649-A HERBICIDE STAUFFER CHEMICAL COMPANY (US) 1976-07-27 — — US disclosed
US-3965087-A Trisazo dye containing a diphenylenesulfone structure SAKAI CHEMICAL INDUSTRY COMPANY LTD. (JA) 1976-06-22 — — US disclosed
US-3956264-A Basic azo dyestuffs having indolyl-methyleneamino substituent in the diazo component BAYER AKTIENGESELLSCHAFT (DT) 1976-05-11 — — US disclosed
US-3951941-A POLYAZODYE SAKAI CHEMICAL INDUSTRY COMPANY, LIMITED (JA) 1976-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250296935-A1 Diamine Derivatives as Inhibitors of Leukotriene A4 Hydrolase LTA4H, LTB4R, LTC4S MAOA 163/4885MAOB 47/4885ALDH1A1 1403/4885
US-20040002521-A1 Cyclopropanecarboxylic acid amide compound and pharmaceutical use thereof NFKBIA, IKBKB, CHUK MAOA 2032/4885MAOB 1642/4885ALDH1A1 2224/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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