Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 4/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786969 | 1.00 | SYK (0.51) | SYKIDO1MEN1GAAKMT2A | |
| SCHEMBL12472349 | 0.90 | SYK (0.49) | SYKIDO1MEN1GAAKMT2A | |
| SCHEMBL30572143 | 0.90 | SYK (0.52) | SYKIDO1MEN1GAAKMT2A | |
| SCHEMBL2598790 | 0.87 | SYK (0.59) | SYKIDO1MEN1KMT2APPARA | |
| SCHEMBL21780574 | 0.86 | SYK (0.52) | SYKIDO1MEN1GAAKMT2A | |
| SCHEMBL2138934 | 0.84 | SLC1A3 (0.61) | MEN1KMT2AMAPTL3MBTL1SLC1A3 | |
| SCHEMBL2141425 | 0.84 | SLC1A3 (0.61) | MEN1KMT2AMAPTL3MBTL1SLC1A3 | |
| SCHEMBL2138927 | 0.84 | SLC1A3 (0.61) | MEN1KMT2AMAPTL3MBTL1SLC1A3 | |
| SCHEMBL1569320 | 0.84 | SYK (0.50) | SYKIDO1MEN1GAAKMT2A | |
| SCHEMBL9073845 | 0.82 | CYP3A4 (0.51) | SYKIDO1MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12146004-B2 | Polymyxin compounds and uses thereof | SPERO THERAPEUTICS, INC. (US) | 2024-11-19 | — | — | US | disclosed |
| US-20230340026-A1 | COMPOUNDS | NEW PHARMA LICENCE HOLDINGS LTD (MT) | 2023-10-26 | — | — | US | disclosed |
| US-20230340026-A1 | COMPOUNDS | NEW PHARMA LICENCE HOLDINGS LTD (MT) | 2023-10-26 | — | — | US | disclosed |
| US-20230340026-A1 | COMPOUNDS | NEW PHARMA LICENCE HOLDINGS LTD (MT) | 2023-10-26 | — | — | US | disclosed |
| US-20180030092-A1 | COMPOUNDS | SPERO THERAPEUTICS, INC. | 2018-02-01 | — | — | US | disclosed |
| US-20180030092-A1 | COMPOUNDS | SPERO THERAPEUTICS, INC. | 2018-02-01 | — | — | US | disclosed |
| US-20180030092-A1 | COMPOUNDS | SPERO THERAPEUTICS, INC. | 2018-02-01 | — | — | US | disclosed |
| EP-3224273-A1 | COMPOUNDS | New Pharma Licence Holdings Limited (MT) | 2017-10-04 | — | — | EP | disclosed |
| CN-107108699-A | Compound | 新药物许可控股有限公司 | 2017-08-29 | — | — | CN | disclosed |
| WO-2016083531-A1 | COMPOUNDS | NEW PHARMA LICENCE HOLDINGS LIMITED (MT) | 2016-06-02 | — | — | WO | disclosed |
| WO-2016083531-A1 | COMPOUNDS | NEW PHARMA LICENCE HOLDINGS LIMITED (MT) | 2016-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230340026-A1 | COMPOUNDS | BCAT1, BCAT2, CCNT1 | SYK 2393/4885IDO1 449/4885MEN1 1609/4885 |
| US-20180030092-A1 | COMPOUNDS | BCAT1, BCAT2, IL4I1 | SYK 1988/4885IDO1 534/4885MEN1 1503/4885 |
| US-12146004-B2 | Polymyxin compounds and uses thereof | BCAT1, BCAT2, PNISR | SYK 1349/4885IDO1 801/4885MEN1 2808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.