SCHEMBL17799763

SCHEMBL17799763

O=C(N[C@H]1CC[C@H]1c1ccc(Cl)cc1Cl)c1ccsc1Br

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 3/20 0.44
▸ NPC1 O15118 2/20 0.44
▸ SMN1; SMN2 Q16637 2/20 0.44
▸ TAS1R3 Q7RTX0 1/20 0.40
▸ TAS1R1 Q7RTX1 1/20 0.40
▸ TAS1R2 Q8TE23 1/20 0.40
▸ CNR1 P21554 3/20 0.37
▸ SLC6A12 P48065 1/20 0.36
▸ DPP4 P27487 3/20 0.36
▸ MEN1 O00255 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ CNR2 P34972 1/20 0.35
▸ F10 P00742 1/20 0.35
▸ HCRTR2 O43614 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17799737 0.88 RAB9A (0.46) RAB9ANPC1SMN1; SMN2TAS1R3TAS1R1
SCHEMBL17799675 0.86 RAB9A (0.44) RAB9ANPC1SMN1; SMN2TAS1R3TAS1R1
SCHEMBL17799697 0.85 NPC1 (0.40) RAB9ANPC1SMN1; SMN2TAS1R3TAS1R1
SCHEMBL17799658 0.83 FPR1 (0.37) RAB9ANPC1SMN1; SMN2TAS1R3TAS1R1
SCHEMBL17799645 0.82 GAA (0.44) RAB9ANPC1SMN1; SMN2TAS1R3TAS1R1
SCHEMBL17799710 0.81 NPC1 (0.47) RAB9ANPC1SMN1; SMN2TAS1R3TAS1R1
SCHEMBL17799743 0.80 SLC6A12 (0.47) RAB9ANPC1TAS1R3TAS1R1TAS1R2
SCHEMBL17799666 0.80 TAS1R3 (0.43) RAB9ANPC1SMN1; SMN2TAS1R3TAS1R1
SCHEMBL17799747 0.80 TAS1R3 (0.39) RAB9ANPC1TAS1R3TAS1R1TAS1R2
SCHEMBL17799731 0.79 TSHR (0.54) RAB9ANPC1SMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE50724-E1 4-membered ring carboxamides used as nematicides SYNGENTA CROP PROTECTION AG (CH) 2026-01-06 — — US disclosed
EP-3019476-B1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2018-01-17 — — EP disclosed
US-9867371-B2 4-membered ring carboxamides used as nematicides SYNGENTA PARTICIPATIONS AG (CH) 2018-01-16 — — US disclosed
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2016-06-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES TUBA3C, DDT, CYCS RAB9A 1776/4885NPC1 1078/4885SMN1; SMN2 678/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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