SCHEMBL17799737

SCHEMBL17799737

O=C(N[C@H]1CC[C@H]1c1ccc(Cl)cc1Cl)c1ccsc1Cl

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 3/20 0.46
▸ NPC1 O15118 2/20 0.46
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ TAS1R3 Q7RTX0 1/20 0.42
▸ TAS1R1 Q7RTX1 1/20 0.42
▸ TAS1R2 Q8TE23 1/20 0.42
▸ SLC6A12 P48065 1/20 0.38
▸ DPP4 P27487 2/20 0.37
▸ MEN1 O00255 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ F10 P00742 1/20 0.36
▸ HCRTR2 O43614 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ SLC6A9 P48067 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17799675 0.88 RAB9A (0.44) RAB9ANPC1SMN1; SMN2TAS1R3TAS1R1
SCHEMBL17799763 0.88 RAB9A (0.44) RAB9ANPC1SMN1; SMN2TAS1R3TAS1R1
SCHEMBL17799645 0.84 GAA (0.44) RAB9ANPC1SMN1; SMN2TAS1R3TAS1R1
SCHEMBL17799650 0.83 FPR1 (0.38) RAB9ANPC1SMN1; SMN2TAS1R3TAS1R1
SCHEMBL17799697 0.82 NPC1 (0.40) RAB9ANPC1SMN1; SMN2TAS1R3TAS1R1
SCHEMBL17799743 0.81 SLC6A12 (0.47) RAB9ANPC1TAS1R3TAS1R1TAS1R2
SCHEMBL17799722 0.81 HPGD (0.41) RAB9ATAS1R3TAS1R1TAS1R2HCRTR2
SCHEMBL17799731 0.81 TSHR (0.54) RAB9ANPC1SMN1; SMN2MEN1KMT2A
SCHEMBL17799764 0.79 TAS1R3 (0.52) RAB9ANPC1TAS1R3TAS1R1TAS1R2
SCHEMBL16372239 0.79 SIGMAR1 (0.45) RAB9ANPC1TAS1R3TAS1R1TAS1R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE50724-E1 4-membered ring carboxamides used as nematicides SYNGENTA CROP PROTECTION AG (CH) 2026-01-06 — — US disclosed
EP-3019476-B1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2018-01-17 — — EP disclosed
US-9867371-B2 4-membered ring carboxamides used as nematicides SYNGENTA PARTICIPATIONS AG (CH) 2018-01-16 — — US disclosed
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2016-06-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES TUBA3C, DDT, CYCS RAB9A 1776/4885NPC1 1078/4885SMN1; SMN2 678/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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