Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | MMP9 | P14780 | 2/20 | 0.30 |
| ▸ | MMP8 | P22894 | 2/20 | 0.30 |
| ▸ | MMP13 | P45452 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801039 | 0.80 | HCAR3 (0.43) | CNR2CNR1RXRARXRBRXRG | |
| SCHEMBL17801061 | 0.78 | KMT2A (0.38) | CNR2CNR1RXRARXRBRXRG | |
| SCHEMBL4079306 | 0.76 | NPC1 (0.41) | CNR2CNR1RXRARXRBRXRG | |
| SCHEMBL18548025 | 0.76 | DGAT2 (0.40) | CNR2CNR1RXRARXRBRXRG | |
| SCHEMBL30182911 | 0.73 | MAPT (0.38) | CNR2RXRARXRBRXRGDGAT2 | |
| SCHEMBL17801013 | 0.73 | HDAC1 (0.42) | DGAT2 | |
| SCHEMBL17801066 | 0.72 | HCRTR1 (0.40) | RXRARXRBRXRG | |
| SCHEMBL5378173 | 0.71 | RAB9A (0.41) | CNR2CNR1ALDH1A1RAB9ACYP2C19 | |
| SCHEMBL30950223 | 0.69 | CYP4F2 (0.39) | RXRARXRBRXRGDGAT2ALDH1A1 | |
| SCHEMBL22160453 | 0.69 | CYP4F2 (0.39) | RXRARXRBRXRGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |