SCHEMBL17801296

SCHEMBL17801296

Cn1cc(C(=O)CCl)cn1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.53
SMN1; SMN2 Q16637 3/20 0.53
L3MBTL1 Q9Y468 2/20 0.53
HTT P42858 1/20 0.53
GRN P28799 1/20 0.44
SORT1 Q99523 1/20 0.44
HPGD P15428 3/20 0.42
LMNA P02545 2/20 0.42
ACHE P22303 3/20 0.41
RAB9A P51151 1/20 0.41
GSK3B P49841 2/20 0.41
TRPA1 O75762 1/20 0.41
MAPK1 P28482 1/20 0.41
HIF1A Q16665 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
MAPT P10636 1/20 0.41
CYP2C19 P33261 1/20 0.41
PROKR1 Q8TCW9 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12221255 0.82 SMN1; SMN2 (0.45) ALDH1A1SMN1; SMN2L3MBTL1HTTGRN
SCHEMBL12221241 0.81 ACHE (0.58) ALDH1A1SMN1; SMN2L3MBTL1HTTGRN
SCHEMBL15143106 0.81 SMN1; SMN2 (0.44) ALDH1A1SMN1; SMN2L3MBTL1HTTGRN
SCHEMBL24340341 0.81 SMN1; SMN2 (0.44) ALDH1A1SMN1; SMN2L3MBTL1HTTGRN
SCHEMBL1506111 0.81 SMN1; SMN2 (0.44) ALDH1A1SMN1; SMN2L3MBTL1HTTGRN
Bromide SCHEMBL16212289 0.79 SMN1; SMN2 (0.43) ALDH1A1SMN1; SMN2L3MBTL1HTTGRN
SCHEMBL2558328 0.78 SMN1; SMN2 (0.42) ALDH1A1SMN1; SMN2L3MBTL1HTTGRN
SCHEMBL17570796 0.78 SMN1; SMN2 (0.46) ALDH1A1SMN1; SMN2L3MBTL1HTTGRN
SCHEMBL368970 0.78
SCHEMBL28147463 0.77 VNN1 (0.49) ALDH1A1SMN1; SMN2L3MBTL1HTTGRN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747249-A1 TREM2 MODULATORS Muna Therapeutics ApS (DK) 2026-05-27 EP disclosed
US-12459953-B2 TREM2 modulators MUNA THERAPEUTICS APS (DK) 2025-11-04 US disclosed
US-20250223294-A1 TREM2 MODULATORS MUNA THERAPEUTICS APS (DK) 2025-07-10 US disclosed
EP-4551575-A2 TREM2 MODULATORS Muna Therapeutics ApS (DK) 2025-05-14 EP disclosed
CN-119403806-A TREM2 modulators 穆纳治疗有限公司 2025-02-07 CN disclosed
WO-2025017059-A1 TREM2 MODULATORS MUNA THERAPEUTICS APS (DK) 2025-01-23 WO disclosed
US-20240309003-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE VIGIL NEUROSCIENCE, INC. (US) 2024-09-19 US disclosed
EP-4334295-A2 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE Vigil Neuoscience, Inc. (US) 2024-03-13 EP disclosed
CN-117597333-A Heterocyclic compounds as receptor 2-triggering agonists expressed on myeloid cells and methods of use 维吉尔神经科学股份有限公司 2024-02-23 CN disclosed
WO-2024008722-A2 TREM2 MODULATORS MUNA THERAPEUTICS APS (DK) 2024-01-11 WO disclosed
US-11028093-B2 4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors ARRAY BIOPHARMA INC. (US) 2021-06-08 US disclosed
EP-3227297-B1 4,6-SUBSTITUTED-PYRAZOLO[1,5-A]PYRAZINES AS JANUS KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2021-01-20 EP disclosed
US-20200291039-A1 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2020-09-17 US disclosed
US-10730880-B2 4,6-substituted-pyrazolo[1,5-a]pyrazines as Janus kinase inhibitors ARRAY BIOPHARMA INC. (US) 2020-08-04 US disclosed
US-20200055860-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC 2020-02-20 US disclosed
US-20190177328-A1 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2019-06-13 US disclosed
US-10189845-B2 4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors ARRAY BIOPHARMA INC. (US) 2019-01-29 US disclosed
US-20170362240-A1 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2017-12-21 US disclosed
EP-3227297-A1 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS Array Biopharma, Inc. (US) 2017-10-11 EP disclosed
WO-2016090285-A1 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2016-06-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12459953-B2 TREM2 modulators FCER2, MERTK, FCGR1A ALDH1A1 4399/4885SMN1; SMN2 188/4885L3MBTL1 3602/4885
US-20200291039-A1 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS JAK1, JAK3, JAK2 ALDH1A1 1526/4885SMN1; SMN2 4032/4885L3MBTL1 559/4885
US-10730880-B2 4,6-substituted-pyrazolo[1,5-a]pyrazines as Janus kinase inhibitors JAK1, JAK3, JAK2 ALDH1A1 1526/4885SMN1; SMN2 4032/4885L3MBTL1 559/4885
US-20190177328-A1 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS JAK1, JAK3, JAK2 ALDH1A1 1526/4885SMN1; SMN2 4032/4885L3MBTL1 559/4885
US-20240309003-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE MSR1, FPR2, CD14 ALDH1A1 2654/4885SMN1; SMN2 472/4885L3MBTL1 4809/4885
US-20170362240-A1 4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS JAK1, JAK3, JAK2 ALDH1A1 1526/4885SMN1; SMN2 4032/4885L3MBTL1 559/4885
US-20200055860-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, ROR1 ALDH1A1 3241/4885SMN1; SMN2 1094/4885L3MBTL1 1495/4885
US-10189845-B2 4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors JAK1, JAK3, JAK2 ALDH1A1 1526/4885SMN1; SMN2 4032/4885L3MBTL1 559/4885
US-11028093-B2 4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors JAK1, JAK3, JAK2 ALDH1A1 1526/4885SMN1; SMN2 4032/4885L3MBTL1 559/4885
US-20250223294-A1 TREM2 MODULATORS FCER2, MERTK, FCGR1A ALDH1A1 4399/4885SMN1; SMN2 188/4885L3MBTL1 3602/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.