Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.68 |
| ▸ | MAP2K4 | P45985 | 8/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.60 |
| ▸ | IDO1 | P14902 | 1/20 | 0.60 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.60 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.51 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GYS1 | P13807 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029772 | 0.80 | TRPA1 (0.68) | TRPA1MAP2K4MAPK1MAPK6MAPKAPK5 | |
| SCHEMBL4027845 | 0.79 | MAP2K4 (0.78) | TRPA1MAP2K4MAPK1MAPK6MAPKAPK5 | |
| SCHEMBL1513065 | 0.79 | MAP2K4 (0.70) | TRPA1MAP2K4MAPK1MAPK6IDO1 | |
| SCHEMBL17829918 | 0.78 | IDO1 (0.65) | MAP2K4MAPK1MAPK6IDO1MAPKAPK5 | |
| SCHEMBL22819365 | 0.76 | MAP2K4 (1.00) | TRPA1MAP2K4MAPK1MAPK6MAPKAPK5 | |
| SCHEMBL22801763 | 0.75 | MAP2K4 (1.00) | TRPA1MAP2K4MAPK1MAPK6MAPKAPK5 | |
| SCHEMBL17832991 | 0.74 | DYRK1A (0.59) | TRPA1ALDH1A1HPGDGSK3B | |
| SCHEMBL11683028 | 0.73 | IDO1 (0.71) | MAP2K4IDO1MAPKAPK2ALDH1A1MAPT | |
| SCHEMBL2662677 | 0.72 | TRPA1 (0.56) | TRPA1MAP2K4MAPK1MAPK6MAPKAPK5 | |
| SCHEMBL17829604 | 0.71 | MAP2K4 (0.66) | TRPA1MAP2K4MAPK1MAPK6MAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3229593-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | Synereca Pharmaceuticals, Inc. (US) | 2017-10-18 | — | — | EP | disclosed |
| US-20160168140-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | SYNERECA PHARMACEUTICALS (US) | 2016-06-16 | — | — | US | disclosed |
| US-20160168140-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | SYNERECA PHARMACEUTICALS (US) | 2016-06-16 | — | — | US | disclosed |
| WO-2016094730-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | SYNERECA PHARMACEUTICALS, INC. (US) | 2016-06-16 | — | — | WO | disclosed |
| WO-2016094730-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | SYNERECA PHARMACEUTICALS, INC. (US) | 2016-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168140-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | FOS, FOSB, YAP1 | TRPA1 1229/4885MAP2K4 793/4885MAPK1 192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.