Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.65 |
| ▸ | ITK | Q08881 | 4/20 | 0.52 |
| ▸ | MAP2K4 | P45985 | 9/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.48 |
| ▸ | MAPKAPK3 | Q16644 | 5/20 | 0.48 |
| ▸ | MAPK6 | Q16659 | 5/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.48 |
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17818474 | 0.78 | TRPA1 (0.68) | IDO1MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL4005413 | 0.77 | MAP2K4 (0.65) | IDO1ITKMAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL11683028 | 0.76 | IDO1 (0.71) | IDO1MAP2K4MAPKAPK2ALDH1A1MAPT | |
| SCHEMBL8269417 | 0.74 | ITK (0.50) | ITKMAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL27191613 | 0.72 | MAP2K4 (0.71) | ITKMAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL31021959 | 0.72 | LRRK2 (0.61) | ITKMAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL13525178 | 0.72 | JAK2 (0.52) | PDPK1IKBKB | |
| SCHEMBL27341653 | 0.72 | ITK (0.46) | ITKMAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL14081507 | 0.71 | MAP2K4 (0.71) | ITKMAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL30442416 | 0.71 | IDO1 (0.51) | IDO1MAPK1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160168140-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | SYNERECA PHARMACEUTICALS (US) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168140-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | FOS, FOSB, YAP1 | IDO1 4129/4885ITK 2269/4885MAP2K4 793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.