Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 7/20 | 0.48 |
| ▸ | HTR2C known ✓ | P28335 | 7/20 | 0.48 |
| ▸ | HTR2B known ✓ | P41595 | 7/20 | 0.48 |
| ▸ | DRD2 known ✓ | P14416 | 6/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL17819175 | 1.00 | HTR2A (0.48) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL16432958 | 0.96 | DRD2 (0.46) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL17819167 | 0.95 | DRD2 (0.45) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL17819176 | 0.93 | FAAH (0.44) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL428300 | 0.90 | F10 (0.45) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL16439292 | 0.87 | DCUN1D1 (0.47) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL16432783 | 0.87 | DRD2 (0.45) | SIGMAR1DRD2ALDH1A1FAAHCES2 | |
| Hydrochloric Acid SCHEMBL17819156 | 0.86 | DRD2 (0.44) | SIGMAR1DRD2ALDH1A1FAAHCES2 | |
| SCHEMBL16433073 | 0.85 | FAAH (0.44) | SIGMAR1SMN1; SMN2FAAHCES2DCUN1D1 | |
| SCHEMBL16433000 | 0.85 | FAAH (0.45) | HTR2AHTR2CHTR2BSIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160166560-A1 | Urea Compounds and Their Use as FAAH Enzyme Inhibitors | BIAL-PORTELA & CA, S.A. (PT) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160166560-A1 | Urea Compounds and Their Use as FAAH Enzyme Inhibitors | FAAH, FAAH2, HRH2 | HTR2A 579/4885HTR2C 203/4885HTR2B 138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.