Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 6/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.58 |
| ▸ | RORB | Q92753 | 10/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10092890 | 0.89 | RORB (0.65) | CDK5CDK5R1RORBCCNA2CDK2 | |
| SCHEMBL257393 | 0.89 | RORB (0.60) | CDK5CDK5R1RORBCCNA2CDK2 | |
| SCHEMBL178218 | 0.85 | ADORA3 (0.60) | RORBRORCADORA3ADORA2AADORA1 | |
| SCHEMBL257438 | 0.83 | ADORA3 (0.54) | RORBRORCADORA3ADORA2AADORA1 | |
| SCHEMBL10092883 | 0.81 | RORB (0.67) | RORBCCNA2CDK2RORCADORA3 | |
| SCHEMBL168526 | 0.81 | RORB (0.70) | RORBCCNA2CDK2RORCADORA1 | |
| SCHEMBL257615 | 0.80 | RORB (0.72) | RORBCCNA2CDK2RORCADORA2A | |
| SCHEMBL257616 | 0.80 | ADORA3 (0.64) | RORBADORA3ADORA2AADORA1 | |
| SCHEMBL10092885 | 0.79 | RORB (0.70) | RORBRORCADORA3ADORA2AADORA1 | |
| SCHEMBL257436 | 0.79 | RORB (0.66) | RORBRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027965-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012027965-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |