Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 9/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10092883 | 0.92 | RORB (0.67) | RORBCCNA2CDK2ALDH1A1ADORA2A | |
| SCHEMBL257615 | 0.91 | RORB (0.72) | RORBCCNA2CDK2ALDH1A1ADORA2A | |
| SCHEMBL178204 | 0.89 | CDK5 (0.58) | RORBCCNA2CDK2ADORA2AADORA3 | |
| SCHEMBL178218 | 0.88 | ADORA3 (0.60) | RORBALDH1A1ADORA2AADORA3ADORA1 | |
| SCHEMBL10092885 | 0.87 | RORB (0.70) | RORBADORA2AADORA3ADORA1MAPT | |
| SCHEMBL257438 | 0.86 | ADORA3 (0.54) | RORBALDH1A1ADORA2AADORA3ADORA1 | |
| SCHEMBL257432 | 0.85 | RORB (0.74) | RORBCCNA2CDK2ALDH1A1ADORA2A | |
| SCHEMBL10092890 | 0.83 | RORB (0.65) | RORBCCNA2CDK2RORCCDK5 | |
| SCHEMBL257616 | 0.83 | ADORA3 (0.64) | RORBALDH1A1ADORA2AADORA3ADORA1 | |
| SCHEMBL257394 | 0.82 | RORB (0.61) | RORBCCNA2CDK2ALDH1A1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027965-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |