Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9065946 | 0.77 | ALDH1A1 (0.42) | LMNAALDH1A1P2RX7CYP17A1CNR2 | |
| Hydrochloric Acid SCHEMBL2116807 | 0.72 | LMNA (0.38) | LMNAALDH1A1GLAP2RX7CYP17A1 | |
| Hydrochloric Acid SCHEMBL2114200 | 0.69 | LMNA (0.38) | LMNAALDH1A1GLAP2RX7CYP17A1 | |
| Hydrochloric Acid SCHEMBL9065650 | 0.69 | P2RX7 (0.42) | LMNAALDH1A1P2RX7CYP17A1CNR2 | |
| Hydrochloric Acid SCHEMBL2114509 | 0.69 | LMNA (0.37) | LMNAALDH1A1GLAP2RX7CYP17A1 | |
| Hydrochloric Acid SCHEMBL2117005 | 0.66 | LMNA (0.39) | LMNAALDH1A1GLAP2RX7CYP17A1 | |
| SCHEMBL23220249 | 0.63 | THRB (0.63) | LMNAALDH1A1GLAMEN1KMT2A | |
| SCHEMBL2841738 | 0.63 | THRB (0.63) | LMNAALDH1A1GLAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7044171 | 0.61 | HTT (0.50) | LMNAALDH1A1GLAP2RX7CYP17A1 | |
| Hydrochloric Acid SCHEMBL28131943 | 0.61 | THRB (0.61) | LMNAALDH1A1GLAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0766702-B1 | POLYMERIZATION CATALYST SYSTEMS, THEIR PRODUCTION AND USE | EXXONMOBIL CHEM PATENTS INC (US) | 2001-10-17 | — | — | EP | disclosed |
| US-5863853-A | MIXING A SOLUTION OF METALLOCENE AND ACTIVATOR WITH A POROUS SUPPORT, DRYING TO FORM A CATALYST SUPPORT FOR ADDITION POLYMERIZATION | EXXON CHEMICAL PATENTS, INC. (US) | 1999-01-26 | — | — | US | disclosed |
| EP-0766702-A1 | POLYMERIZATION CATALYST SYSTEMS, THEIR PRODUCTION AND USE | EXXON CHEMICAL PATENTS INC. (US) | 1997-04-09 | — | — | EP | disclosed |
| WO-1996000245-A1 | POLYMERIZATION CATALYST SYSTEMS, THEIR PRODUCTION AND USE | EXXON CHEMICAL PATENTS INC. (US) | 1996-01-04 | — | — | WO | disclosed |