Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474258 | 0.84 | OPRD1 (0.38) | ALDH1A1OPRD1OPRK1OPRM1 | |
| SCHEMBL19598956 | 0.81 | GPR119 (0.52) | — | |
| SCHEMBL17847937 | 0.73 | OPRD1 (0.46) | OPRD1OPRK1OPRM1KCNH2 | |
| SCHEMBL12777868 | 0.71 | SETD7 (0.41) | HPGDOPRD1OPRK1OPRM1 | |
| SCHEMBL12708214 | 0.71 | OPRD1 (0.69) | ALDH1A1HPGDOPRD1OPRK1OPRM1 | |
| SCHEMBL17843398 | 0.70 | POLB (0.43) | ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL12432540 | 0.70 | SETD7 (0.47) | ALDH1A1HPGDSMN1; SMN2OPRD1TP53 | |
| SCHEMBL25253125 | 0.70 | MYC (0.46) | ALDH1A1HPGDTP53 | |
| SCHEMBL12730808 | 0.70 | OPRD1 (0.53) | ALDH1A1HPGDOPRD1OPRK1OPRM1 | |
| SCHEMBL29008622 | 0.70 | HDAC6 (0.50) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233825-B1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES AND THEIR USE AS DELTA OPIOID RECEPTOR AGONISTS | PHARMNOVO AB (SE) | 2020-04-29 | — | — | EP | disclosed |
| US-10118921-B2 | Diarylmethylidene piperidine derivatives and their use as delta opoid receptor agnists | PHARMNOVO AB (SE) | 2018-11-06 | — | — | US | disclosed |
| US-20170327491-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES AND THEIR USE AS DELTA OPOID RECEPTOR AGNISTS | PHARMNOVO AB (SE) | 2017-11-16 | — | — | US | disclosed |
| EP-3233825-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES AND THEIR USE AS DELTA OPIOID RECEPTOR AGONISTS | Pharmnovo AB (SE) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016099393-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES AND THEIR USE AS DELTA OPIOID RECEPTOR AGONISTS | PHARMNOVO AB (SE) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10118921-B2 | Diarylmethylidene piperidine derivatives and their use as delta opoid receptor agnists | OPRD1, OPRM1, OPRK1 | ALDH1A1 716/4885HPGD 562/4885SMN1; SMN2 1863/4885 |
| US-20170327491-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES AND THEIR USE AS DELTA OPOID RECEPTOR AGNISTS | OPRD1, OPRM1, OPRK1 | ALDH1A1 716/4885HPGD 562/4885SMN1; SMN2 1863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.