Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 11/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | GUSB | P08236 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BCL6 | P41182 | 1/20 | 0.31 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16623480 | 0.89 | MAPK14 (0.34) | RORCPARP1MAPK14GUSB | |
| SCHEMBL17849205 | 0.86 | DGAT1 (0.32) | MAPK14GUSBALDH1A1 | |
| SCHEMBL17849236 | 0.86 | RORC (0.36) | RORCPARP1MAPK14 | |
| SCHEMBL16623600 | 0.82 | TYK2 (0.34) | PARP1MAPK14 | |
| SCHEMBL16726665 | 0.81 | ALDH2 (0.33) | — | |
| SCHEMBL16623544 | 0.80 | MEN1 (0.32) | MAPK14 | |
| SCHEMBL16623547 | 0.78 | SYK (0.36) | ALDH1A1 | |
| SCHEMBL16623468 | 0.77 | MPO (0.31) | RAB9A | |
| SCHEMBL17849215 | 0.77 | CRBN (0.38) | — | |
| SCHEMBL16726696 | 0.75 | HDAC6 (0.41) | RORCALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |