Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 5/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | KLK1 | P06870 | 1/20 | 0.31 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | GUSB | P08236 | 1/20 | 0.31 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.30 |
| ▸ | RRM1 | P23921 | 2/20 | 0.30 |
| ▸ | RRM2B | Q7LG56 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17849237 | 0.89 | RORC (0.33) | MAPK14RORCPARP1GUSB | |
| SCHEMBL16623554 | 0.86 | MAPK14 (0.33) | MAPK14KMT2AF10F2PLG | |
| SCHEMBL16623600 | 0.82 | TYK2 (0.34) | MAPK14PARP1ERN1KAT6A | |
| SCHEMBL16623479 | 0.75 | CRBN (0.40) | KDR | |
| SCHEMBL17849205 | 0.75 | DGAT1 (0.32) | MAPK14F10GUSB | |
| SCHEMBL17849236 | 0.74 | RORC (0.36) | MAPK14RORCPARP1KMT2A | |
| SCHEMBL17849219 | 0.73 | RAF1 (0.42) | MAPK14KMT2A | |
| SCHEMBL16623552 | 0.73 | DDB1 (0.32) | — | |
| SCHEMBL16623485 | 0.70 | PARP1 (0.37) | PARP1KMT2AERN1 | |
| SCHEMBL16623511 | 0.70 | TYK2 (0.38) | PARP1KAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |