Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | APC | P25054 | 2/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17850414 | 0.80 | HPGD (0.40) | WDR5JAK2HPGDALDH1A1 | |
| SCHEMBL10194739 | 0.77 | FLT3 (0.43) | HTR2BJAK2MAPK14 | |
| SCHEMBL10194916 | 0.73 | IDO1 (0.42) | WDR5KMT2AHPGDALDH1A1 | |
| SCHEMBL10195458 | 0.72 | DRD2 (0.42) | KMT2AHPGDALDH1A1 | |
| SCHEMBL10195780 | 0.69 | ESRRA (0.44) | WDR5ALDH1A1 | |
| SCHEMBL10196924 | 0.68 | L3MBTL3 (0.43) | HRH3HPGDALDH1A1 | |
| SCHEMBL10195446 | 0.68 | PIK3CA (0.42) | WDR5KMT2AHPGD | |
| SCHEMBL10195439 | 0.68 | PHGDH (0.35) | KMT2AHTR2BJAK2HPGDALDH1A1 | |
| SCHEMBL10194732 | 0.67 | ESRRA (0.44) | WDR5ALDH1A1 | |
| SCHEMBL17850412 | 0.67 | ESRRA (0.48) | WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |