Benzamide

Benzamide

SCHEMBL1785440

NC(=O)c1ccccc1.Oc1ccccc1

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 3/20 0.80
TDP1 Q9NUW8 2/20 0.80
MAPT P10636 2/20 0.80
TSHR P16473 2/20 0.80
POLB P06746 1/20 0.80
CYP3A4 P08684 1/20 0.80
CYP2C19 P33261 1/20 0.80
RECQL P46063 1/20 0.80
BLM P54132 1/20 0.80
PMP22 Q01453 1/20 0.80
HSD17B10 Q99714 1/20 0.80
L3MBTL1 Q9Y468 1/20 0.80
CES2 O00748 3/20 0.56
CA12 O43570 2/20 0.55
CA1 P00915 2/20 0.55
CA2 P00918 2/20 0.55
CA9 Q16790 2/20 0.55
GLA P06280 1/20 0.55
CA3 P07451 1/20 0.55
CA4 P22748 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzamide SCHEMBL9619649 1.00 PARP1 (0.80) PARP1TDP1MAPTTSHRPOLB
Benzamide SCHEMBL10890603 0.93 MAPT (0.76) PARP1TDP1MAPTTSHRPOLB
Benzamide SCHEMBL30112947 0.89 PARP1 (1.00) PARP1TDP1MAPTTSHRPOLB
Benzamide SCHEMBL6690447 0.89 PARP1 (1.00) PARP1TDP1MAPTTSHRPOLB
Benzamide SCHEMBL29618402 0.89
Benzamide SCHEMBL1332331 0.89
Benzamide SCHEMBL16352 0.89
Benzamide SCHEMBL1222101 0.89 PARP1 (1.00) PARP1TDP1MAPTTSHRPOLB
SCHEMBL21755166 0.89 PARP1 (1.00) PARP1TDP1MAPTTSHRPOLB
Benzamide SCHEMBL27963599 0.89 PARP1 (1.00) PARP1TDP1MAPTTSHRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130203730-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2013-08-08 US disclosed
EP-2607357-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS Astrazeneca AB (SE) 2013-06-26 EP disclosed
US-20120115845-A1 THERAPEUTIC AGENTS ALLEN JACK MCQUEEN (GB) 2012-05-10 US disclosed
US-20110124621-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2011-05-26 US disclosed
EP-2205576-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS AstraZeneca AB (SE) 2010-07-14 EP disclosed
US-20090186870-A1 Therapeutic Agents - 802 ASTRAZENECA AB (SE) 2009-07-23 US disclosed
WO-2009047558-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2009-04-16 WO disclosed
CN-1126451-C Improved dithiocarbamate bactericide composition DOW YINON INC (US) 2003-11-05 CN disclosed
CN-1234179-A Improved dithiocarbamate bactericide composition ROHM & HAAS (US) 1999-11-10 CN disclosed
EP-0213984-B1 INDOLE CARBOXAMIDE DERIVATIVES, THEIR SALTS, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM ROUSSEL-UCLAF (FR) 1991-01-09 EP disclosed
EP-0213984-A1 Indole carboxamide derivatives, their salts, process and intermediates for their preparation, their use as medicines and compositions containing them ROUSSEL-UCLAF (FR) 1987-03-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130203730-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS GPR119, GHSR, GLP1R PARP1 4808/4885TDP1 4366/4885MAPT 3413/4885
US-20120115845-A1 THERAPEUTIC AGENTS GPR119, MC2R, MC4R PARP1 4696/4885TDP1 4230/4885MAPT 4086/4885
US-20090186870-A1 Therapeutic Agents - 802 GPR119, SLC5A2, MC2R PARP1 4282/4885TDP1 4334/4885MAPT 4300/4885
US-20110124621-A1 BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS GPR119, GHSR, GLP1R PARP1 4808/4885TDP1 4366/4885MAPT 3413/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.