SCHEMBL178552

SCHEMBL178552

CNC(C)Cc1ccc(F)cc1

nearest known ligand 0.63

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 4/20 0.63
SLC18A2 Q05940 1/20 0.63
SIGMAR1 Q99720 1/20 0.63
SLC6A4 P31645 3/20 0.60
TRPA1 O75762 1/20 0.52
CYP2D6 P10635 1/20 0.47
SLC6A2 P23975 1/20 0.47
SLC6A3 Q01959 1/20 0.47
HTR1B P28222 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8976958 1.00 TAAR1 (0.63) TAAR1SLC18A2SIGMAR1SLC6A4TRPA1
Hydrochloric Acid SCHEMBL23524437 0.98 TAAR1 (0.61) TAAR1SLC18A2SIGMAR1SLC6A4TRPA1
Cadaverine Tartrate SCHEMBL9773333 0.83 TAAR1 (0.50) TAAR1SLC18A2SIGMAR1SLC6A4TRPA1
SCHEMBL16356133 0.83 TRPA1 (0.52) TAAR1SLC18A2SIGMAR1SLC6A4TRPA1
SCHEMBL10076448 0.80 TAAR1 (0.65) TAAR1SLC18A2SIGMAR1SLC6A4CYP2D6
SCHEMBL178625 0.80 TAAR1 (0.65) TAAR1SLC18A2SIGMAR1SLC6A4CYP2D6
SCHEMBL765297 0.80 TAAR1 (0.65) TAAR1SLC18A2SIGMAR1SLC6A4CYP2D6
SCHEMBL4680337 0.79 SIGMAR1 (0.66) SIGMAR1SLC6A4TRPA1CYP2D6
SCHEMBL178533 0.78 TAAR1 (0.63) TAAR1SLC18A2SIGMAR1SLC6A4CYP2D6
SCHEMBL7316113 0.78 TAAR1 (0.63) TAAR1SLC18A2SIGMAR1SLC6A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4615585-A1 METHODS OF USING TRAZODONE TO REVERSE THE EFFECTS OF 5-HT2A RECEPTOR AGONISTS Gilgamesh Pharmaceuticals, Inc. (US) 2025-09-17 EP claimed
WO-2024102458-A1 METHODS OF USING TRAZODONE TO REVERSE THE EFFECTS OF 5-HT2A RECEPTOR AGONISTS GILGAMESH PHARMACEUTICALS, INC. (US) 2024-05-16 WO claimed
US-20160000815-A1 COMPOSITIONS AND METHODS FOR TREATING PSYCHIATRIC DISORDERS GOSFORTH CT HOLDINGS PTY LTD (AU) 2016-01-07 US claimed
US-20140142140-A1 PHARMACEUTICAL COMPOSITION FOR NEUROLOGICAL DISORDERS GOSFORTH CENTRE (HOLDINGS) PTY LTD (AU) 2014-05-22 US claimed
EP-2729216-A1 PHARMACEUTICAL COMPOSITION FOR NEUROLOGICAL DISORDERS Gosforth Centre (Holdings) Pty Ltd (AU) 2014-05-14 EP claimed
WO-2013007698-A1 PHARMACEUTICAL COMPOSITION FOR NEUROLOGICAL DISORDERS GOSFORTH CENTRE (HOLDINGS) PTY LTD (AU) 2013-01-17 WO claimed
JP-2011529923-A 2011-12-15 JP claimed
US-20110207718-A1 COMPOSITIONS AND METHODS FOR TREATING PSYCHIATRIC DISORDERS GOSFORTH CENTRE (HOLDINGS) PTY LTD. (AU) 2011-08-25 US claimed
EP-2331088-A1 COMPOSITIONS AND METHODS FOR TREATING PSYCHIATRIC DISORDERS Gosforth Centre (Holdings) Pty Ltd (AU) 2011-06-15 EP claimed
US-20100172916-A1 SUBSTITUTED HYDROXYPHENYLAMINE COMPOUNDS AUSPEX PHARMACEUTICALS, INC. (US) 2010-07-08 US claimed
WO-2010054286-A2 SUBSTITUTED HYDROXYPHENYLAMINE COMPOUNDS AUSPEX PHARMACEUTICALS, INC. (US) 2010-05-14 WO claimed
WO-2010015029-A1 COMPOSITIONS AND METHODS FOR TREATING PSYCHIATRIC DISORDERS GOSFORTH CENTRE (HOLDINGS) PTY LTD (AU) 2010-02-11 WO claimed
WO-2026106796-A1 SYSTEM AND METHOD FOR THE TREATMENT OF TELOGEN EFFLUVIUM, ANDROGENETIC ALOPECIA, AND OTHER HAIR LOSS DISORDERS FOLLEA INTERNATIONAL (US) 2026-05-21 WO disclosed
EP-3841085-B1 NBOME TEST UNIV SYDNEY TECHNOLOGY (AU) 2026-05-06 EP disclosed
US-20260041652-A1 SYSTEM AND METHOD FOR PREVENTING ALOPECIA FOLLEA INT (US) 2026-02-12 US disclosed
US-20260027148-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS BEXSON BIOMEDICAL INC (US) 2026-01-29 US disclosed
EP-0186680-B1 PHENYLISOPROPYLAMINE DERIVATIVE AND ITS PREPARATION CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) 1988-03-30 EP disclosed
CN-85104166-A Preparation of new medicine and its preparation 1986-11-26 CN disclosed
EP-0186680-A1 PHENYLISOPROPYLAMINE DERIVATIVE AND ITS PREPARATION. CHINOIN GYOGYSZER ES VEGYESZET (HU) 1986-07-09 EP disclosed
WO-1985005617-A1 PHENYLISOPROPYLAMINE DERIVATIVE AND ITS PREPARATION Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. (HU) 1985-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100172916-A1 SUBSTITUTED HYDROXYPHENYLAMINE COMPOUNDS MC1R, TYR, MITF TAAR1 1451/4885SLC18A2 244/4885SIGMAR1 773/4885
US-20260027148-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS SLC6A3, SIGMAR1, SLC6A4 TAAR1 48/4885SLC18A2 11/4885SIGMAR1 2/4885
US-20260041652-A1 SYSTEM AND METHOD FOR PREVENTING ALOPECIA DYRK4, DYRK2, STRA6 TAAR1 370/4885SLC18A2 1819/4885SIGMAR1 4868/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.