Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ME2 | P23368 | 1/20 | 0.40 |
| ▸ | ME1 | P48163 | 1/20 | 0.40 |
| ▸ | ME3 | Q16798 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15259145 | 0.84 | ESR2 (0.42) | ALDH1A1MAPK1KDM4EMAPTLMNA | |
| SCHEMBL277239 | 0.82 | AKR1C2 (0.44) | NPC1RAB9A | |
| SCHEMBL8404738 | 0.82 | RAB9A (0.48) | ALDH1A1HPGDMAPK1KDM4EMAPT | |
| SCHEMBL277402 | 0.81 | ALAD (0.39) | ALDH1A1HPGDMAPK1KDM4EMAPT | |
| SCHEMBL1784106 | 0.81 | PTGS1 (0.48) | HPGDMAPK1MAPTLMNAPTGS2 | |
| SCHEMBL277465 | 0.81 | ABL1 (0.40) | ALDH1A1HPGDKDM4EMAPTGAA | |
| SCHEMBL13720856 | 0.81 | SLC2A1 (0.40) | ALDH1A1MAPK1KDM4EMAPTESR2 | |
| SCHEMBL280393 | 0.80 | MAPT (0.53) | ALDH1A1HPGDKDM4EMAPTLMNA | |
| SCHEMBL12607270 | 0.78 | PTGS1 (0.39) | HPGDMAPTPTGS2PKMSMN1; SMN2 | |
| SCHEMBL277174 | 0.78 | AKR1C2 (0.41) | HPGDMAPTLMNASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2439204-B1 | HETEROCYCLIC COMPOUND AND HEMATOPOIETIC STEM CELL AMPLIFIER | NISSAN CHEMICAL IND LTD (JP) | 2017-01-04 | — | — | EP | disclosed |
| EP-2246343-B1 | PROCESS FOR PRODUCTION OF THIOPHENE COMPOUND AND INTERMEDIATE THEREOF | NISSAN CHEMICAL IND LTD (JP) | 2016-05-18 | — | — | EP | disclosed |
| US-9328085-B2 | Heterocyclic compounds and expansion agents for hematopoietic stem cells | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2016-05-03 | — | — | US | disclosed |
| US-20140051857-A1 | HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES LIMITED (JP) | 2014-02-20 | — | — | US | disclosed |
| US-8642786-B2 | Process for producing thiophene compound and intermediate thereof | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2014-02-04 | — | — | US | disclosed |
| US-20140005413-A2 | PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATE THEREOF | NISSAN CHEMICAL IND LTD (JP) | 2014-01-02 | — | — | US | disclosed |
| US-20130245255-A1 | HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-09-19 | — | — | US | disclosed |
| US-20130204013-A1 | PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATE THEREOF | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-08-08 | — | — | US | disclosed |
| US-20130204013-A1 | PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATE THEREOF | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-08-08 | — | — | US | disclosed |
| US-8420849-B2 | Process for producing thiophene compound and intermediate thereof | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-04-16 | — | — | US | disclosed |
| US-20110077290-A1 | HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES LIMITED (JP) | 2011-03-31 | — | — | US | disclosed |
| WO-2010140685-A1 | HETEROCYCLIC COMPOUND AND HEMATOPOIETIC STEM CELL AMPLIFIER | 日産化学工業株式会社 (JP) | 2010-12-09 | — | — | WO | disclosed |
| EP-2246343-A1 | PROCESS FOR PRODUCTION OF THIOPHENE COMPOUND AND INTERMEDIATE THEREOF | Nissan Chemical Industries, Ltd. (JP) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009107799-A1 | PROCESS FOR PRODUCTION OF THIOPHENE COMPOUND AND INTERMEDIATE THEREOF | 日産化学工業株式会社 (JP) | 2009-09-03 | — | — | WO | disclosed |
| US-7576115-B2 | Heterocyclic compounds and thrombopoietin receptor activators | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2009-08-18 | — | — | US | disclosed |
| US-7576115-B2 | Heterocyclic compounds and thrombopoietin receptor activators | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2009-08-18 | — | — | US | disclosed |
| US-7351841-B2 | Heterocyclic compounds and thrombopoietin receptor activators | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2008-04-01 | — | — | US | disclosed |
| US-7351841-B2 | Heterocyclic compounds and thrombopoietin receptor activators | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2008-04-01 | — | — | US | disclosed |
| US-20080027068-A1 | HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES LIMITED (JP) | 2008-01-31 | — | — | US | disclosed |
| US-20080027068-A1 | HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES LIMITED (JP) | 2008-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245255-A1 | HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS | HCLS1, RUNX1, RCC1 | ALDH1A1 291/4885HPGD 750/4885CYP3A4 2288/4885 |
| US-20130204013-A1 | PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATE THEREOF | TST, SULT1E1, GRHPR | ALDH1A1 102/4885HPGD 834/4885CYP3A4 27/4885 |
| US-20110077290-A1 | HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NR2C2, ROR1, NR0B2 | ALDH1A1 3234/4885HPGD 1739/4885CYP3A4 372/4885 |
| US-20080027068-A1 | HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NR2C2, ROR1, NR0B2 | ALDH1A1 3206/4885HPGD 1694/4885CYP3A4 353/4885 |
| US-20140051857-A1 | HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NR2C2, ROR1, NR0B2 | ALDH1A1 3234/4885HPGD 1739/4885CYP3A4 372/4885 |
| US-20140005413-A2 | PROCESS FOR PRODUCING THIOPHENE COMPOUND AND INTERMEDIATE THEREOF | TST, SULT1E1, GRHPR | ALDH1A1 102/4885HPGD 834/4885CYP3A4 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.