Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 7/20 | 1.00 |
| ▸ | DRD2 | P14416 | 7/20 | 1.00 |
| ▸ | DRD3 | P35462 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | BCHE | P06276 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | HTR7 | P34969 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 2/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949387 | 0.88 | DRD2 (0.79) | DRD4DRD2DRD3LMNAHTT | |
| SCHEMBL5198132 | 0.79 | LMNA (0.72) | DRD4DRD2DRD3LMNAHTT | |
| SCHEMBL9037358 | 0.77 | DRD2 (0.63) | DRD4DRD2DRD3LMNAHTT | |
| SCHEMBL4772684 | 0.77 | KDM4E (0.69) | DRD4DRD2DRD3LMNAHTT | |
| Ether SCHEMBL27933270 | 0.77 | HTR6 (0.84) | DRD4DRD2DRD3LMNAHTT | |
| SCHEMBL4775148 | 0.76 | DRD2 (0.62) | DRD4DRD2DRD3LMNAHTT | |
| SCHEMBL5198952 | 0.76 | DRD2 (0.63) | DRD4DRD2DRD3LMNAHTT | |
| SCHEMBL948662 | 0.76 | HTR6 (1.00) | DRD4DRD2DRD3LMNAHTT | |
| SCHEMBL5198142 | 0.75 | LMNA (0.70) | DRD4DRD2DRD3LMNAHTT | |
| SCHEMBL12126924 | 0.75 | DRD4 (0.73) | DRD4DRD2DRD3HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110124657-A1 | METHOD FOR SCREENING OF 5HT7 RECEPTOR LIGANDS BASED ON A NEW PHARMACOPHORE MODEL AND A DESCRIPTOR'S PROFILE FILTER | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-05-26 | — | — | US | claimed |
| EP-2151777-A1 | Method for screening of 5HT7 receptor ligands based on a new pharmacophore model and a descriptor's profile filter | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2010-02-10 | — | — | EP | claimed |
| US-20110183991-A1 | 5HT7 RECEPTOR LIGANDS AND COMPOSITIONS COMPRISING THE SAME | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-07-28 | — | — | US | disclosed |
| US-20110124657-A1 | METHOD FOR SCREENING OF 5HT7 RECEPTOR LIGANDS BASED ON A NEW PHARMACOPHORE MODEL AND A DESCRIPTOR'S PROFILE FILTER | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-05-26 | — | — | US | disclosed |
| US-20110124657-A1 | METHOD FOR SCREENING OF 5HT7 RECEPTOR LIGANDS BASED ON A NEW PHARMACOPHORE MODEL AND A DESCRIPTOR'S PROFILE FILTER | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-05-26 | — | — | US | disclosed |
| US-20110124657-A1 | METHOD FOR SCREENING OF 5HT7 RECEPTOR LIGANDS BASED ON A NEW PHARMACOPHORE MODEL AND A DESCRIPTOR'S PROFILE FILTER | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-05-26 | — | — | US | disclosed |
| EP-2151777-A1 | Method for screening of 5HT7 receptor ligands based on a new pharmacophore model and a descriptor's profile filter | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2010-02-10 | — | — | EP | disclosed |
| EP-2149373-A1 | 5HT7 receptor ligands and compositions comprising the same | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2010-02-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183991-A1 | 5HT7 RECEPTOR LIGANDS AND COMPOSITIONS COMPRISING THE SAME | HTR7, HTR1A, HTR6 | DRD4 70/4885DRD2 43/4885DRD3 131/4885 |
| US-20110124657-A1 | METHOD FOR SCREENING OF 5HT7 RECEPTOR LIGANDS BASED ON A NEW PHARMACOPHORE MODEL AND A DESCRIPTOR'S PROFILE FILTER | HTR7, HTR1A, HTR2C | DRD4 41/4885DRD2 40/4885DRD3 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.