Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.38 |
| ▸ | F2 | P00734 | 5/20 | 0.38 |
| ▸ | F10 | P00742 | 5/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.38 |
| ▸ | F7 | P08709 | 5/20 | 0.38 |
| ▸ | F3 | P13726 | 5/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATF4 | P18848 | 1/20 | 0.36 |
| ▸ | SPIN1 | Q9Y657 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17888600 | 0.94 | AKR1C3 (0.39) | AKR1C3AKR1C2F2F10PRSS1 | |
| SCHEMBL17899158 | 0.87 | AKR1C3 (0.41) | AKR1C3AKR1C2F10PRSS1PRSS2 | |
| SCHEMBL17931447 | 0.86 | MAPT (0.40) | AKR1C3AKR1C2F2F10PRSS1 | |
| SCHEMBL17888653 | 0.84 | AKR1C3 (0.39) | AKR1C3AKR1C2MAPTSPIN1SYK | |
| SCHEMBL17888571 | 0.84 | PDE4D (0.40) | MAPTATF4PARP10PDE4APDE4B | |
| SCHEMBL17888568 | 0.84 | PDE4D (0.40) | MAPTATF4PARP10PDE4APDE4B | |
| SCHEMBL17888576 | 0.84 | PDE4D (0.40) | MAPTATF4PARP10PDE4APDE4B | |
| SCHEMBL23190672 | 0.84 | SPIN1 (0.38) | AKR1C3AKR1C2F10PRSS1PRSS2 | |
| SCHEMBL17888529 | 0.83 | AKR1C3 (0.39) | AKR1C3AKR1C2MAPTSPIN1PARP10 | |
| SCHEMBL17899379 | 0.83 | RAB9A (0.38) | AKR1C3AKR1C2MAPTSPIN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11013728-B2 | Cyclin-dependent kinase 8 and/or 19 inhibitor | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2021-05-25 | — | — | US | disclosed |
| US-20210100783-A1 | NOVEL CYCLIN-DEPENDENT KINASE 8 AND/OR 19 INHIBITOR | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2021-04-08 | — | — | US | disclosed |
| EP-3607944-A1 | NOVEL CYCLIN-DEPENDENT KINASE 8 AND/OR 19 INHIBITOR | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2020-02-12 | — | — | EP | disclosed |
| US-20160207883-A1 | NOVEL AROMATIC COMPOUND AND USE THEREOF | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2016-07-21 | — | — | US | disclosed |
| US-20160207883-A1 | NOVEL AROMATIC COMPOUND AND USE THEREOF | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2016-07-21 | — | — | US | disclosed |
| EP-3040329-A1 | NOVEL AROMATIC COMPOUND AND USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2016-07-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207883-A1 | NOVEL AROMATIC COMPOUND AND USE THEREOF | SOST, BMP2, ALPI | AKR1C3 721/4885AKR1C2 1087/4885F2 2090/4885 |
| US-20210100783-A1 | NOVEL CYCLIN-DEPENDENT KINASE 8 AND/OR 19 INHIBITOR | CCNI, CDK9, CDK8 | AKR1C3 2658/4885AKR1C2 2210/4885F2 4578/4885 |
| US-11013728-B2 | Cyclin-dependent kinase 8 and/or 19 inhibitor | CCNI, CDK9, CDKN1A | AKR1C3 2920/4885AKR1C2 2502/4885F2 4610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.