Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 2/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1794793 | 0.87 | PGK1 (0.45) | PGK1PDK1PDK2PDK3PDK4 | |
| SCHEMBL17672911 | 0.81 | ALK (0.42) | PGK1PDK1PDK2PDK3PDK4 | |
| SCHEMBL1799535 | 0.78 | AR (0.42) | ALKPTGDR2ARL3MBTL1 | |
| SCHEMBL29236456 | 0.77 | PGK1 (0.43) | PGK1CNR1CNR2HSD11B1AR | |
| SCHEMBL30966841 | 0.77 | PGK1 (0.43) | PGK1CNR1CNR2HSD11B1AR | |
| SCHEMBL1798406 | 0.75 | AR (0.42) | ALKARL3MBTL1FNTAFNTB | |
| SCHEMBL6865029 | 0.75 | KIF11 (0.45) | ALKL3MBTL1 | |
| SCHEMBL3838602 | 0.74 | VCAM1 (0.50) | PTGDR2VCAM1ARACACBSLC22A12 | |
| SCHEMBL29898505 | 0.74 | VCAM1 (0.50) | PTGDR2VCAM1ARACACBSLC22A12 | |
| SCHEMBL1798290 | 0.73 | VCAM1 (0.40) | PTGDR2VCAM1ARACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951827-B2 | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2011-05-31 | — | — | US | disclosed |
| US-20060264487-A1 | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles | TIDWELL RICHARD R | 2006-11-23 | — | — | US | disclosed |
| EP-1719767-A1 | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles | The University of North Carolina at Chapel Hill (US) | 2006-11-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264487-A1 | Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles | PFAS, DHPS, DDO | PGK1 486/4885PDK1 482/4885PDK2 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.