Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | RHOC | P08134 | 3/20 | 0.55 |
| ▸ | RHOA | P61586 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.52 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | MYLK | Q15746 | 1/20 | 0.52 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.52 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1799371 | 0.89 | RHOC (0.53) | MPORHOCRHOAMEN1KMT2A | |
| SCHEMBL1797569 | 0.84 | SERPINE1 (0.56) | MEN1KMT2AGAAMAPTSERPINE1 | |
| SCHEMBL1795944 | 0.80 | SERPINE1 (0.45) | MPOMEN1KMT2AGAASERPINE1 | |
| SCHEMBL1015269 | 0.80 | GRIK1 (0.52) | MEN1KMT2AGAAMAPTP2RX1 | |
| SCHEMBL1015135 | 0.79 | GRIK1 (0.51) | MEN1KMT2AGAAMAPTP2RX1 | |
| SCHEMBL418647 | 0.77 | SERPINE1 (0.66) | MPOSERPINE1KDM4EHSD17B10PPARG | |
| SCHEMBL1015619 | 0.76 | SERPINE1 (0.49) | GAAMAPTSERPINE1POLBG6PD | |
| SCHEMBL1796212 | 0.76 | TP53 (0.69) | MEN1KMT2AGAAMAPTSERPINE1 | |
| SCHEMBL1015276 | 0.76 | SERPINE1 (0.65) | GAASERPINE1POLBG6PDKDM4E | |
| SCHEMBL1012592 | 0.75 | SERPINE1 (0.64) | GAASERPINE1POLBG6PDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951806-B2 | Plasminogen activator inhibitor-1 inhibitor | RENASCIENCE CO., LTD. (JP) | 2011-05-31 | — | — | US | claimed |
| US-20090124620-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | RENASCIENCE CO., LTD. (JP) | 2009-05-14 | — | — | US | claimed |
| US-10092537-B2 | Use for PAI-1 inhibitor | RENASCIENCE CO., LTD. (JP) | 2018-10-09 | — | — | US | disclosed |
| US-20160158188-A1 | NOVEL USE FOR PAI-1 INHIBITOR | RENASCIENCE CO., LTD. (JP) | 2016-06-09 | — | — | US | disclosed |
| EP-2990057-A1 | NOVEL USE FOR PAI-1 INHIBITOR | Renascience Co., Ltd. (JP) | 2016-03-02 | — | — | EP | disclosed |
| US-7951806-B2 | Plasminogen activator inhibitor-1 inhibitor | RENASCIENCE CO., LTD. (JP) | 2011-05-31 | — | — | US | disclosed |
| US-20090124620-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | RENASCIENCE CO., LTD. (JP) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160158188-A1 | NOVEL USE FOR PAI-1 INHIBITOR | SERPINE1, SERPINC1, SERPINB1 | MPO 534/4885RHOC 4404/4885RHOA 3874/4885 |
| US-20090124620-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | SERPINE1, SERPINC1, SERPINB1 | MPO 183/4885RHOC 3393/4885RHOA 751/4885 |
| US-10092537-B2 | Use for PAI-1 inhibitor | SERPINE1, SERPINC1, SERPINB1 | MPO 407/4885RHOC 4442/4885RHOA 3851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.