SCHEMBL1799580

SCHEMBL1799580

CC(C)C1=Cc2c(-c3ccc(C(C)(C)C)cc3)cccc2C1[Si](C)(C)Cl

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
S1PR1 P21453 1/20 0.32
PTAFR P25105 1/20 0.31
BRD4 O60885 1/20 0.31
CREBBP Q92793 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30541994 1.00 NPC1 (0.33) NPC1RAB9ALMNATP53SMN1; SMN2
SCHEMBL5552751 0.90 NPC1 (0.34) NPC1RAB9ALMNATP53SMN1; SMN2
SCHEMBL27337741 0.90 NPC1 (0.34) NPC1RAB9ALMNATP53SMN1; SMN2
SCHEMBL16394493 0.89
SCHEMBL5548696 0.87 NR1H4 (0.30)
SCHEMBL5607400 0.87
SCHEMBL3688821 0.86 ADRA2A (0.31)
SCHEMBL29695859 0.86 S1PR1 (0.33) NPC1RAB9ALMNATP53SMN1; SMN2
SCHEMBL12617135 0.85 NPC1 (0.31) NPC1RAB9ALMNATP53SMN1; SMN2
SCHEMBL5549218 0.84 BRD4 (0.30) BRD4CREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12065560-B2 Propylene-ethylene random copolymer LG CHEM, LTD. (KR) 2024-08-20 US disclosed
US-20240209126-A1 HYBRID SUPPORTED METALLOCENE CATALYST AND METHOD FOR PREPARING POLYPROPYLENE USING THE SAME LG CHEM, LTD. (KR) 2024-06-27 US disclosed
US-20240209126-A1 HYBRID SUPPORTED METALLOCENE CATALYST AND METHOD FOR PREPARING POLYPROPYLENE USING THE SAME LG CHEM, LTD. (KR) 2024-06-27 US disclosed
EP-3936542-B1 PROPYLENE-ETHYLENE RANDOM COPOLYMER LG CHEMICAL LTD (KR) 2023-11-08 EP disclosed
CN-113840845-B Propylene-ethylene random copolymer 株式会社LG化学 2023-08-18 CN disclosed
US-20220213303-A1 Propylene-Ethylene Random Copolymer LG CHEM, LTD. (KR) 2022-07-07 US disclosed
EP-3936542-A1 PROPYLENE-ETHYLENE RANDOM COPOLYMER LG CHEM, LTD. (KR) 2022-01-12 EP disclosed
CN-113840845-A Propylene-ethylene random copolymer 株式会社LG化学 2021-12-24 CN disclosed
WO-2020251264-A1 PROPYLENE-ETHYLENE RANDOM COPOLYMER 주식회사 엘지화학 2020-12-17 WO disclosed
US-7951970-B2 Process for recycling cyclopentadienyl derivatives and preparing metallocenes from recycled, substituted cyclopentadienyl derivatives BASELL POLYOLEFINE GMBH (DE) 2011-05-31 US disclosed
EP-1448578-B1 METALLOCENE COMPOUNDS AND PROCESS FOR THE PREPARATION OF PROPYLENE POLYMERS BASELL POLYOLEFINE GMBH (DE) 2006-07-26 EP disclosed
US-20050182266-A1 Transition metal componds their preparation and their use in catalyst systems for the polymerization and copolymerization of olefins BASELL POLYOLEFINE GMBH (DE) 2005-08-18 US disclosed
WO-2005058916-A2 ORGANOMETALLIC TRANSITION METAL COMPOUND, BISCYCLOPENTADIENYL LIGAND SYSTEM, CATALYST SYSTEM AND PREPARATION OF POLYOLEFINS BASELL POLYOLEFINE GMBH (DE) 2005-06-30 WO disclosed
EP-1511755-A1 TRANSITION METAL COMPOUNDS THEIR PREPARATION AND THEIR USE IN CATALYST SYSTEMS FOR THE POLYMERIZATION AND COPOLYMERIZATION OF OLEFINS Basell Polyolefine GmbH (DE) 2005-03-09 EP disclosed
US-20050010058-A1 Such as {Dimethyl-silyl-(5-isopropyl-2-methyl-3-phenyl-cyclopento[2,3-b]thiophen-6-yl)-(2-methyl-4-phenyl-[3a,4-dihydro]azulen-1-yl)}ZrCl2 catalyst for homo or copolymerization of propylene EXXONMOBIL CHEMICAL PATENTS INC. 2005-01-13 US disclosed
EP-1492749-A1 PREPARATION OF SUBSTITUTED INDENES Basell Polyolefine GmbH (DE) 2005-01-05 EP disclosed
EP-1448578-A1 METALLOCENE COMPOUNDS AND PROCESS FOR THE PREPARATION OF PROPYLENE POLYMERS Basell Polyolefine GmbH (DE) 2004-08-25 EP disclosed
WO-2003106470-A1 TRANSITION METAL COMPOUNDS THEIR PREPARATION AND THEIR USE IN CATALYST SYSTEMS FOR THE POLYMERIZATION AND COPOLYMERIZATION OF OLEFINS BASELL POLYOLEFINE GMBH (DE) 2003-12-24 WO disclosed
WO-2003084904-A1 PREPARATION OF SUBSTITUTED INDENES BASELL POLYOLEFINE GMBH (DE) 2003-10-16 WO disclosed
WO-2003045964-A1 METALLOCENE COMPOUNDS AND PROCESS FOR THE PREPARATION OF PROPYLENE POLYMERS BASELL POLYOLEFINE GMBH (DE) 2003-06-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050010058-A1 Such as {Dimethyl-silyl-(5-isopropyl-2-methyl-3-phenyl-cyclopento[2,3-b]thiophen-6-yl)-(2-methyl-4-phenyl-[3a,4-dihydro]azulen-1-yl)}ZrCl2 catalyst for homo or copolymerization of propylene CHRM1, YWHAZ, PYM1 NPC1 3795/4885RAB9A 2871/4885LMNA 2328/4885
US-20050182266-A1 Transition metal componds their preparation and their use in catalyst systems for the polymerization and copolymerization of olefins YAP1, COX14, CYCS NPC1 2049/4885RAB9A 4420/4885LMNA 3778/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.