Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 6/20 | 0.84 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CTSV | O60911 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17999733 | 1.00 | SNCA (0.84) | SNCAMAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL21751995 | 0.91 | SNCA (1.00) | SNCAMAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL29406423 | 0.86 | SNCA (0.73) | SNCAMAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL19918109 | 0.86 | SNCA (0.73) | SNCAMAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL17999730 | 0.80 | SNCA (0.68) | SNCAMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL1208152 | 0.79 | SNCA (0.86) | SNCAMAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL29850622 | 0.79 | SNCA (0.86) | SNCAMAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL17999665 | 0.76 | SNCA (1.00) | SNCAMAPTLMNASMN1; SMN2CTSV | |
| SCHEMBL21771119 | 0.75 | SNCA (0.71) | SNCAMAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL21752000 | 0.74 | SNCA (1.00) | SNCAMAPTLMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295101-A1 | THERAPEUTIC COMPOUNDS | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2023-09-21 | — | — | US | disclosed |
| US-11560360-B2 | Therapeutic compounds | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2023-01-24 | — | — | US | disclosed |
| US-20220081404-A1 | PHENOTHIAZINE ANALOGUES AS MITOCHONDRIAL THERAPEUTIC AGENTS | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2022-03-17 | — | — | US | disclosed |
| US-11034662-B2 | Substituted phenothiazines as mitochondrial agents | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2021-06-15 | — | — | US | disclosed |
| US-20200407333-A1 | THERAPEUTIC COMPOUNDS | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2020-12-31 | — | — | US | disclosed |
| EP-3258938-B1 | PHENOTHIAZINE ANALOGUES AS MITOCHONDRIAL THERAPEUTIC AGENTS | UNIV ARIZONA STATE (US) | 2020-12-02 | — | — | EP | disclosed |
| US-10745366-B2 | Therapeutic compounds | ARIZON BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2020-08-18 | — | — | US | disclosed |
| US-20200115355-A1 | PHENOTHIAZINE ANALOGUES AS MITOCHONDRIAL THERAPEUTIC AGENTS | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2020-04-16 | — | — | US | disclosed |
| US-10472340-B2 | Substituted phenothiazines as mitochondrial agents | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2019-11-12 | — | — | US | disclosed |
| US-20190185441-A1 | THERAPEUTIC COMPOUNDS | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2019-06-20 | — | — | US | disclosed |
| US-20180065941-A1 | PHENOTHIAZINE ANALOGUES AS MITOCHONDRIAL THERAPEUTIC AGENTS | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2018-03-08 | — | — | US | disclosed |
| WO-2018039487-A1 | THERAPEUTIC COMPOUNDS | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2018-03-01 | — | — | WO | disclosed |
| EP-3258938-A1 | PHENOTHIAZINE ANALOGUES AS MITOCHONDRIAL THERAPEUTIC AGENTS | Arizona Board of Regents on behalf of Arizona State University (US) | 2017-12-27 | — | — | EP | disclosed |
| WO-2016133995-A1 | PHENOTHIAZINE ANALOGUES AS MITOCHONDRIAL THERAPEUTIC AGENTS | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2016-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180065941-A1 | PHENOTHIAZINE ANALOGUES AS MITOCHONDRIAL THERAPEUTIC AGENTS | GSR, COQ8A, TXNRD2 | SNCA 766/4885MAPT 634/4885LMNA 1915/4885 |
| US-20200115355-A1 | PHENOTHIAZINE ANALOGUES AS MITOCHONDRIAL THERAPEUTIC AGENTS | GSR, COQ8A, TXNRD2 | SNCA 766/4885MAPT 634/4885LMNA 1915/4885 |
| US-10472340-B2 | Substituted phenothiazines as mitochondrial agents | GSR, TXN2, PCK2 | SNCA 584/4885MAPT 812/4885LMNA 1334/4885 |
| US-20200407333-A1 | THERAPEUTIC COMPOUNDS | CFTR, MC2R, RPS21 | SNCA 1861/4885MAPT 2395/4885LMNA 1071/4885 |
| US-11560360-B2 | Therapeutic compounds | CFTR, MC2R, RPS21 | SNCA 1861/4885MAPT 2395/4885LMNA 1071/4885 |
| US-20230295101-A1 | THERAPEUTIC COMPOUNDS | CFTR, C1R, FURIN | SNCA 2990/4885MAPT 1136/4885LMNA 1361/4885 |
| US-11034662-B2 | Substituted phenothiazines as mitochondrial agents | GSR, SQOR, MT-ATP6 | SNCA 585/4885MAPT 1504/4885LMNA 2032/4885 |
| US-20190185441-A1 | THERAPEUTIC COMPOUNDS | CFTR, C1R, FURIN | SNCA 2990/4885MAPT 1136/4885LMNA 1361/4885 |
| US-10745366-B2 | Therapeutic compounds | CFTR, C1R, FURIN | SNCA 2990/4885MAPT 1136/4885LMNA 1361/4885 |
| US-20220081404-A1 | PHENOTHIAZINE ANALOGUES AS MITOCHONDRIAL THERAPEUTIC AGENTS | GSR, COQ8A, TXNRD2 | SNCA 766/4885MAPT 634/4885LMNA 1915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.