Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 4/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 2/20 | 0.33 |
| ▸ | SGK1 | O00141 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18007218 | 0.86 | AXL (0.37) | TNKSHSD17B1HSD17B2AURKAMAPT | |
| SCHEMBL18007256 | 0.79 | PTGS2 (0.38) | TNKSAURKAMAPTTHRBCASP1 | |
| SCHEMBL7941636 | 0.65 | ALDH1A1 (0.44) | HSD17B1HSD17B2MAPTKDM4EALDH1A1 | |
| SCHEMBL2160705 | 0.65 | GRIN2D (0.59) | ALDH1A1HPGD | |
| SCHEMBL2160707 | 0.65 | GRIN2D (0.59) | ALDH1A1HPGD | |
| SCHEMBL3323469 | 0.65 | GRIN2D (0.59) | ALDH1A1HPGD | |
| SCHEMBL13910991 | 0.65 | HSD17B1 (0.63) | HSD17B1HSD17B2AXLKDRKDM4E | |
| SCHEMBL30587086 | 0.64 | ALDH1A1 (0.50) | ALDH1A1HPGD | |
| SCHEMBL18015479 | 0.64 | HSD17B1 (0.59) | HSD17B1HSD17B2DYRK1AKDM4EHPGDS | |
| SCHEMBL19794431 | 0.64 | LDHA (0.50) | HSD17B1HSD17B2DYRK1AHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3259262-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PERAMPANEL | Mapi Pharma Limited (IL) | 2017-12-27 | — | — | EP | disclosed |
| WO-2016132343-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PERAMPANEL | MAPI PHARMA LTD. (IL) | 2016-08-25 | — | — | WO | disclosed |