Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.49 |
| ▸ | MMP13 | P45452 | 4/20 | 0.49 |
| ▸ | MMP3 | P08254 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | MMP9 | P14780 | 6/20 | 0.47 |
| ▸ | BMP1 | P13497 | 5/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | ADAM8 | P78325 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP7 | P09237 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358332 | 0.91 | MMP2 (0.47) | MMP2MMP13MMP3CA12CA1 | |
| SCHEMBL8358421 | 0.91 | BMP1 (0.54) | MMP2MMP13MMP3CA12CA1 | |
| SCHEMBL1799177 | 0.91 | BMP1 (0.58) | MMP2MMP13MMP3MMP9BMP1 | |
| SCHEMBL6472806 | 0.84 | TARS1 (0.50) | MMP2MMP13MMP3CA12CA1 | |
| SCHEMBL1800122 | 0.84 | MMP2 (0.65) | MMP2MMP13MMP3MMP9ITGB3 | |
| SCHEMBL1244355 | 0.83 | ITGB3 (0.60) | MMP2CA12CA2CA9MMP9 | |
| SCHEMBL3448321 | 0.83 | MMP9 (0.58) | MMP2MMP13MMP3MMP9ITGB3 | |
| SCHEMBL3448325 | 0.83 | MMP9 (0.58) | MMP2MMP13MMP3MMP9ITGB3 | |
| SCHEMBL12619409 | 0.83 | MMP2 (0.54) | MMP2MMP13MMP3MMP9BMP1 | |
| Hydrochloric Acid SCHEMBL7319933 | 0.82 | ITGB3 (0.59) | MMP2CA12CA2CA9MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951972-B2 | Human adam-10 inhibitors | EXELIXIS, INC. (US) | 2011-05-31 | — | — | US | disclosed |